Frick J C, Hansen R M, Anderson T, Ritch P S
Arch Intern Med. 1986 Apr;146(4):791-2.
A patient with systemic recurrence of large-cell malignant lymphoma developed radiologic evidence of parenchymal brain metastasis. Treatment with systemic high-dose cytarabine resulted in complete regression of peripheral adenopathy and complete radiologic response in the central nervous system, with normalization of the brain computed tomographic scan. This case further demonstrates the ability of high-dose cytarabine to penetrate the blood-brain barrier and achieve therapeutic drug concentrations in the central nervous system, an area that might otherwise remain a pharmacologic sanctuary for tumor cells.
一名患有大细胞恶性淋巴瘤全身复发的患者出现了脑实质转移的影像学证据。全身大剂量阿糖胞苷治疗导致外周淋巴结病完全消退，中枢神经系统出现完全的影像学反应，脑部计算机断层扫描恢复正常。该病例进一步证明了大剂量阿糖胞苷穿透血脑屏障并在中枢神经系统达到治疗药物浓度的能力，否则该区域可能仍是肿瘤细胞的药物庇护所。
