Alharbi Sultan R
Department of Radiology and Medical Imaging, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
J Clin Imaging Sci. 2024 Nov 27;14:46. doi: 10.25259/JCIS_129_2024. eCollection 2024.
The objective of this study was to evaluate complete contrast staining (CCS) of HCC during drug-eluting bead transarterial chemoembolization (DEBTACE) first session for response prediction.
Forty-one patients with solitary HCC who underwent DEBTACE were retrospectively enrolled and divided into two groups based on contrast staining of HCC using two-dimensional (2D) fluoroscopy during the first session of DEBTACE. Both groups underwent one or two sessions of DEBTACE to achieve a complete response. Responses were evaluated using the modified Response Evaluation Criteria in Solid Tumors. A comparison of the complete response between the CCS and non-CCS groups was performed, and the prediction value was studied.
CCS in 2D fluoroscopy during the first session of drug-eluting bead chemoembolization was observed in 22 (53.7%) patients. Well-defined HCC and super-selective chemoembolization were significantly associated with CCS. Complete response was observed in 54.54%, 90%, and 95.45% of CCS patient groups after the first session, second session, and cumulative sessions of TACE, respectively. Complete responses were 10.52%, 29.41%, and 36.84% in the non-CCS group after the first, second, and cumulative sessions of TACE, respectively.
CCS of HCC using 2D fluoroscopy during DEBTACE is a predictor of a favorable response after two sessions of treatment.
本研究的目的是评估在药物洗脱微球经动脉化疗栓塞术（DEBTACE）首次治疗期间肝细胞癌的完全对比剂染色（CCS）情况，以预测疗效。
回顾性纳入41例行DEBTACE治疗的孤立性肝细胞癌患者，并根据DEBTACE首次治疗期间使用二维（2D）透视对肝细胞癌的对比剂染色情况分为两组。两组均接受一或两次DEBTACE治疗以达到完全缓解。使用改良的实体瘤疗效评价标准评估疗效。对CCS组和非CCS组的完全缓解情况进行比较，并研究预测价值。
在22例（53.7%）患者的药物洗脱微球化疗栓塞术首次治疗期间的2D透视中观察到CCS。边界清晰的肝细胞癌和超选择性化疗栓塞与CCS显著相关。CCS患者组在TACE首次治疗、第二次治疗和累计治疗后分别有54.54%、90%和95.45%观察到完全缓解。非CCS组在TACE首次治疗、第二次治疗和累计治疗后完全缓解率分别为10.52%、29.41%和36.84%。
DEBTACE期间使用2D透视对肝细胞癌进行CCS是两次治疗后良好疗效的预测指标。
