类风湿关节炎合并间质性肺疾病患者的血清阳性率
Seroprevalence in Rheumatoid Arthritis Patients with Interstitial Lung Disease.
作者信息
Oka Shomi, Higuchi Takashi, Furukawa Hiroshi, Shimada Kota, Okamoto Akira, Fujimori Misuzu, Hashimoto Atsushi, Komiya Akiko, Saisho Koichiro, Yoshikawa Norie, Katayama Masao, Matsui Toshihiro, Fukui Naoshi, Migita Kiyoshi, Tohma Shigeto
机构信息
Department of Rheumatology, NHO Tokyo National Hospital, Kiyose, Japan.
Clinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital, Sagamihara, Japan.
出版信息
Biomark Insights. 2024 Dec 4;19:11772719241297171. doi: 10.1177/11772719241297171. eCollection 2024.
BACKGROUND
Rheumatoid arthritis (RA) is complicated with interstitial lung disease (ILD). Gastroesophageal reflux disease is prevented by infection and is a predisposing factor for idiopathic pulmonary fibrosis. However, the prevalence of infection in RA patients with ILD has not been sufficiently investigated.
OBJECTIVE
In this study, we analyzed anti- antibodies in RA patients with ILD.
DESIGN
Case-control observational study.
METHODS
Anti- antibodies were analyzed in the sera of RA patients using a commercially available enzyme-linked immunosorbent assay kit.
RESULTS
The positivity of anti- antibodies in RA with ILD ( = 30 [18.0%], = .0227), usual interstitial pneumonia ( = 10 [14.3%], = .0212), and airway disease ( = 30 [18.0%], = .0227) was significantly lower than that of RA without chronic lung disease ( = 78 [27.5%]). The positivity of anti- antibodies was also lower in RA with chronic lung disease ( = 68 [18.2%], = .0059). Multiple logistic regression analyses showed that the presence of anti- antibodies was independently and protectively associated with chronic lung disease in RA.
CONCLUSION
The seroprevalence of was lower in RA with ILD. infection prevented ILD in patients with RA by protecting them from gastroesophageal reflux disease.
背景
类风湿关节炎（RA）常合并间质性肺疾病（ILD）。胃食管反流病可由感染预防，且是特发性肺纤维化的一个易感因素。然而，RA合并ILD患者中感染的患病率尚未得到充分研究。
目的
在本研究中，我们分析了RA合并ILD患者的抗抗体。
设计
病例对照观察性研究。
方法
使用市售酶联免疫吸附测定试剂盒分析RA患者血清中的抗抗体。
结果
RA合并ILD（=30 [18.0%]，=0.0227）、寻常型间质性肺炎（=10 [14.3%]，=0.0212）和气道疾病（=30 [18.0%]，=0.0227）患者中抗抗体的阳性率显著低于无慢性肺病的RA患者（=78 [27.5%]）。慢性肺病RA患者中抗抗体的阳性率也较低（=68 [18.2%]，=0.0059）。多因素逻辑回归分析显示，抗抗体的存在与RA患者的慢性肺病独立且具有保护相关性。
结论
RA合并ILD患者中血清阳性率较低。感染通过保护患者免受胃食管反流病的影响来预防RA患者发生ILD。
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