Gupta B B, Jaffrin M Y, Ding L H, Dohi T
Artif Organs. 1986 Feb;10(1):45-51. doi: 10.1111/j.1525-1594.1986.tb02515.x.
The filtration capabilities of small polypropylene hollow-fiber plasma filters with membrane areas ranging from 100 to 1,000 cm2 have been investigated. It is found that the filtration flux per unit membrane area is approximately proportional to the wall shear rate gamma w at least up to gamma w = 7,500 s-1. As a result, the total filtration flow rate increases very little when the number of fibers is increased as the increase in membrane area is offset by the decrease in shear rate, but it increases with the fiber length L as L 2/3. Hemolysis occurs when the transmembrane pressure exceeds a certain threshold, but this threshold is itself an increasing function of shear rate. As a result, it is possible to circulate high blood flow rates even in very small filters (100 cm2) without hemolysis, provided the fiber length is below a critical value.
对膜面积在100至1000平方厘米之间的小型聚丙烯中空纤维血浆过滤器的过滤能力进行了研究。结果发现，至少在壁面剪切速率γw达到7500 s-1之前，单位膜面积的过滤通量与壁面剪切速率γw大致成正比。因此，当纤维数量增加时，总过滤流量增加很少，因为膜面积的增加被剪切速率的降低所抵消，但它随纤维长度L的增加而增加，与L的2/3次方成正比。当跨膜压力超过某个阈值时会发生溶血，但这个阈值本身是剪切速率的增函数。因此，即使在非常小的过滤器（100平方厘米）中，只要纤维长度低于临界值，也有可能在不发生溶血的情况下循环高血流量。
