Gupta B B, Jaffrin M Y, Ding L H
Department of Biological Engineering, University of Technology of Compiegne, France.
Int J Artif Organs. 1989 Jan;12(1):51-8.
Available mathematical models of ultrafiltration have been used to predict changes in maximum plasma filtration rate with wall shear rate for given filters and blood properties. We have done many plasmapheresis experiments in vitro, using hollow-fiber filters (500-1000 cm2) and fresh bovine blood collected on ACD or heparin. The comparison between predicted and experimentally obtained filtration rates was good for models based on the concentration polarization theory and lift velocity theory. In other experiments with pulsatile inlet flow we found that plasma filtration rate increased by 20 to 50% compared to non-pulsatile conditions. These results are in good agreement with the modified model of ultrafiltration incorporating pulsating flow. This paper presents relationships between plasma filtration velocity (steady and pulsating flow) and hemolysis limit as a function of wall shear rate and filter size.
现有的超滤数学模型已被用于预测给定过滤器和血液特性下最大血浆过滤速率随壁面剪切速率的变化。我们使用中空纤维过滤器（500 - 1000平方厘米）和用ACD或肝素采集的新鲜牛血进行了许多体外血浆置换实验。对于基于浓差极化理论和提升速度理论的模型，预测的过滤速率与实验获得的过滤速率之间的比较结果良好。在其他脉动入口流实验中，我们发现与非脉动条件相比，血浆过滤速率提高了20%至50%。这些结果与包含脉动流的超滤修正模型非常吻合。本文给出了作为壁面剪切速率和过滤器尺寸函数的血浆过滤速度（稳定流和脉动流）与溶血极限之间的关系。
