Effect of Mediterranean diet and physical activity on healthcare professional depression, burnout and professional fulfillment during COVID-19.

. The mental health of healthcare professionals, especially during the COVID-19 pandemic, is a critical concern. This study investigates the prevalence of burnout and professional fulfillment, depression and the relationship between physical activity and adherence to the Mediterranean diet with depression, burnout and professional fulfillment among healthcare professionals. . Data were collected through a web-based survey of 567 healthcare professionals. Logistic regression analysis with age and sex adjustment was employed to analyze the results. . The prevalence of depression was 44%, burnout stood at 66% and professional fulfillment was reported at 28%. Adherence to the Mediterranean diet was linked to a reduced risk of depression (odds ratio [] 0.63, 95% confidence interval [CI] [0.41, 0.96],  = 0.033) and physical activity was also associated with a lower risk of depression ( 0.49, 95% CI [0.32, 0.75],  = 0.001). Furthermore, adherence to the Mediterranean diet was associated with a reduced risk of burnout ( 0.49, 95% CI [0.25, 0.98],  = 0.045). . This study highlights the positive impact of physical activity and the Mediterranean diet as lifestyle factors on depression and burnout. These findings have implications for screening, follow-up and timely interventions to support the mental well-being of healthcare professionals.