从兔儿伞中分离和鉴定倍半萜内酯及其抗乳腺癌活性评价
Isolation and Characterization of Sesquiterpene Lactones From Syneilesis aconitifolia and Evaluation of Their Anti-Breast Cancer Activity.
作者信息
Gao Jie, Zhang Cong, Hu Li-Juan, Lin Kuan, Zhou Mei, Zhu Shu-Xiu, Sun Bin-Lian, Liu Wei, Shu Xi-Ji, Gan Guo-Ping, Ye Xian-Sheng, Yang De-Sen
机构信息
College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China.
Hubei Key Laboratory of Cognitive and Affective Disorders, Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, China.
出版信息
Chem Biodivers. 2025 May;22(5):e202402891. doi: 10.1002/cbdv.202402891. Epub 2024 Dec 16.
Two undescribed sesquiterpene lactones (1 and 2), along with two known analogs (3 and 4), were isolated from Syneilesis aconitifolia. Their structures and absolute configurations were elucidated using spectroscopic analysis, ECD calculations, and single crystal x-ray diffraction. Compound 3 exhibited the highest cytotoxic activity against 4T1 cells, with an IC value of 10.89 µM. In addition, compound 3 significantly induced the apoptosis of 4T1 cells at the concentration of 20 µM. Further anticancer study showed that compound 3 distinctly increased the production of intracellular reactive oxygen species.
从林荫千里光中分离出两种未描述的倍半萜内酯（1和2）以及两种已知类似物（3和4）。通过光谱分析、ECD计算和单晶X射线衍射对它们的结构和绝对构型进行了阐明。化合物3对4T1细胞表现出最高的细胞毒性活性，IC值为10.89 μM。此外，化合物3在20 μM浓度下显著诱导4T1细胞凋亡。进一步的抗癌研究表明，化合物3明显增加了细胞内活性氧的产生。
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