乳酰化作为cGAS和免疫的翻译后调节因子。
Lactylation as a post-translational regulator of cGAS and immunity.
作者信息
Liu Haipeng, Ge Baoxue
机构信息
Shanghai Key Laboratory of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China; Key Laboratory of Pathogen-Host Interaction, Ministry of Education, Department of Microbiology and Immunology, Tongji University School of Medicine, Shanghai, China; Clinical Translation Research Center, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
出版信息
Mol Cell. 2024 Dec 5;84(23):4483-4485. doi: 10.1016/j.molcel.2024.11.018.
In a recent paper at Nature, Li et al. reported that alanine-tRNA synthetases AARS1 and AARS2 are lactate sensors and mediate lactylation of cGAS, leading to its inactivation.
在《自然》杂志最近发表的一篇论文中，李等人报道称，丙氨酸 - 转运RNA合成酶AARS1和AARS2是乳酸传感器，并介导cGAS的乳酰化，导致其失活。
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