Keshri Anand K, Rawat Suraj S, Chaudhary Anubha, Sharma Swati, Kapoor Ananya, Mehra Parul, Kaur Rimanpreet, Mishra Amit, Prasad Amit
School of Biosciences and Bioengineering, Indian Institute of Technology Mandi, Mandi, Himachal Pradesh, India.
Cellular and Molecular Neurobiology Unit, Indian Institute of Technology Jodhpur, Rajasthan, India.
Int J Antimicrob Agents. 2025 Jan;65(1):107398. doi: 10.1016/j.ijantimicag.2024.107398. Epub 2024 Dec 4.
Antimicrobial peptides (AMPs) represent a unique group of naturally occurring molecules having diverse biological activities, including potent antimicrobial properties. Among them, LL-37 has emerged as a significant player, demonstrating its multifaceted roles during bacterial, fungal, and viral infections, as well as exhibiting intriguing implications in cancer. This review delves into the versatile functions of LL-37, elucidating its mechanisms of action against microbial pathogens and its potential to modulate immune responses. We explored the efficacy of LL-37 in disrupting bacterial membranes, inhibiting fungal growth, and interfering with viral replication, highlighting its potential as a therapeutic agent against a wide array of infectious diseases. Furthermore, we discussed the emerging role of LL-37 in cancer immunity, where its immunomodulatory effects and direct cytotoxicity towards cancer cells offer novel avenues for cancer therapy in the near future. We provided a comprehensive overview of the activities of LL-37 across various diseases and underscored the importance of further research into harnessing the therapeutic potential of this potential antimicrobial peptide along with other suitable candidates.
抗菌肽（AMPs）是一类独特的天然存在的分子，具有多种生物活性，包括强大的抗菌特性。其中，LL-37已成为一个重要角色，在细菌、真菌和病毒感染过程中展现出多方面作用，并且在癌症方面也有引人关注的影响。本综述深入探讨LL-37的多种功能，阐明其对抗微生物病原体的作用机制及其调节免疫反应的潜力。我们探究了LL-37在破坏细菌膜、抑制真菌生长和干扰病毒复制方面的功效，突出了其作为针对多种传染病的治疗剂的潜力。此外，我们讨论了LL-37在癌症免疫中的新作用，其免疫调节作用和对癌细胞的直接细胞毒性在不久的将来为癌症治疗提供了新途径。我们全面概述了LL-37在各种疾病中的活性，并强调了进一步研究利用这种潜在抗菌肽以及其他合适候选物的治疗潜力的重要性。
