Spoerke D G, Hall A H, Grimes M J, Honea B N, Rumack B H
Am J Emerg Med. 1986 May;4(3):222-4. doi: 10.1016/0735-6757(86)90070-7.
Three patients self-injected the veterinary tranquilizing agent xylazine (Rompun). The first patient developed mild bradycardia and hypotension, miosis, and a feeling of disorientation. The other two patients became apneic and required intubation and mechanical ventilation. Initial mild hypertension followed by mild hypotension and a mildly elevated blood glucose was seen in the second patient, whereas both the second and third patients developed mild bradycardia. Xylazine has structural similarity to the phenothiazines and pharmacological activity similar to clonidine. With increasing veterinary use, the availability and potential for human exposures may also increase.
三名患者自行注射了兽用镇静剂赛拉嗪（隆朋）。第一名患者出现轻度心动过缓和低血压、瞳孔缩小以及定向障碍感。另外两名患者出现呼吸暂停，需要插管和机械通气。第二名患者最初出现轻度高血压，随后出现轻度低血压和血糖轻度升高，而第二名和第三名患者均出现轻度心动过缓。赛拉嗪与吩噻嗪类药物结构相似，药理活性与可乐定相似。随着兽用范围的扩大，人类接触赛拉嗪的可能性和潜在风险也可能增加。
