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Challenges for developing broad-based mucosal vaccines for respiratory viruses.

作者信息

Seo Junghwa, Polster Jordan, Israelow Benjamin, Corbett-Helaire Kizzmekia S, Martinez David R

机构信息

Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.

Department of Microbial Pathogenesis, Yale School of Medicine, New Haven, CT, USA.

出版信息

Nat Biotechnol. 2024 Dec;42(12):1765-1767. doi: 10.1038/s41587-024-02486-8.

DOI:10.1038/s41587-024-02486-8
PMID:39643701
Abstract
摘要

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本文引用的文献

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Vaccine-mediated protection against Merbecovirus and Sarbecovirus challenge in mice.疫苗介导的对 Merbecovirus 和 Sarbecovirus 挑战的保护作用在小鼠中。
Cell Rep. 2023 Oct 31;42(10):113248. doi: 10.1016/j.celrep.2023.113248. Epub 2023 Oct 18.
2
Nanoparticle display of prefusion coronavirus spike elicits S1-focused cross-reactive antibody response against diverse coronavirus subgenera.纳米颗粒展示融合前冠状病毒刺突可引发针对多种冠状病毒亚属的 S1 靶向交叉反应性抗体应答。
Nat Commun. 2023 Oct 4;14(1):6195. doi: 10.1038/s41467-023-41661-4.
3
Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses.
未佐剂化鼻内刺突疫苗引发针对沙贝科病毒的保护性黏膜免疫。
Science. 2022 Nov 25;378(6622):eabo2523. doi: 10.1126/science.abo2523.
4
Intranasal vaccination with lipid-conjugated immunogens promotes antigen transmucosal uptake to drive mucosal and systemic immunity.鼻腔内接种脂质偶联免疫原可促进抗原经黏膜摄取,从而诱导黏膜和系统免疫。
Sci Transl Med. 2022 Jul 20;14(654):eabn1413. doi: 10.1126/scitranslmed.abn1413.
5
Universal Coronavirus Vaccines - An Urgent Need.通用冠状病毒疫苗——迫切需求
N Engl J Med. 2022 Jan 27;386(4):297-299. doi: 10.1056/NEJMp2118468. Epub 2021 Dec 15.
6
A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice.一种广泛交叉反应的抗体可中和并保护小鼠免受沙贝病毒属病毒的攻击。
Sci Transl Med. 2022 Jan 26;14(629):eabj7125. doi: 10.1126/scitranslmed.abj7125.
7
Mucosal vaccines - fortifying the frontiers.黏膜疫苗——强化前沿。
Nat Rev Immunol. 2022 Apr;22(4):236-250. doi: 10.1038/s41577-021-00583-2. Epub 2021 Jul 26.
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Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice.嵌合刺突 mRNA 疫苗可预防小鼠感染 SARS-CoV 属病毒。
Science. 2021 Aug 27;373(6558):991-998. doi: 10.1126/science.abi4506. Epub 2021 Jun 22.
9
Unresponsiveness to inhaled antigen is governed by conventional dendritic cells and overridden during infection by monocytes.对吸入性抗原的无反应性由传统树突状细胞控制,并在感染期间被单核细胞所取代。
Sci Immunol. 2020 Oct 9;5(52). doi: 10.1126/sciimmunol.abb5439.
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SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness.通过原型病原体准备实现的 SARS-CoV-2 mRNA 疫苗设计。
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