• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

肝内胆管癌的分类

Classification of intrahepatic cholangiocarcinoma.

作者信息

El Homsi Maria, Alkhasawneh Ahmad, Arif-Tiwari Hina, Czeyda-Pommersheim Ferenc, Khasawneh Hala, Kierans Andrea Siobhan, Paspulati Raj Mohan, Singh Charanjeet

机构信息

Memorial Sloan Kettering Cancer Center, New York, USA.

UF Health Jacksonville, Jacksonville, USA.

出版信息

Abdom Radiol (NY). 2025 Jun;50(6):2522-2532. doi: 10.1007/s00261-024-04732-8. Epub 2024 Dec 4.

DOI:10.1007/s00261-024-04732-8
PMID:39643732
Abstract

Cholangiocarcinoma is a heterogenous malignancy with various classifications based on location, morphological features, histological features, and actionable genetic mutations. Intrahepatic cholangiocarcinoma (ICC), which arises in and proximal to second order bile ducts, is the second most common primary liver malignancy after hepatocellular carcinoma. In this review, we will discuss ICC risk factors, precursor lesions, various growth, anatomic, morphologic, and histologic classifications, rare variants, and differential diagnoses.

摘要

胆管癌是一种异质性恶性肿瘤，根据位置、形态学特征、组织学特征和可操作的基因突变有多种分类。肝内胆管癌（ICC）起源于二级胆管及其近端，是继肝细胞癌之后第二常见的原发性肝脏恶性肿瘤。在本综述中，我们将讨论肝内胆管癌的危险因素、前驱病变、各种生长方式、解剖学、形态学和组织学分类、罕见变异以及鉴别诊断。

相似文献

1
Classification of intrahepatic cholangiocarcinoma.肝内胆管癌的分类
Abdom Radiol (NY). 2025 Jun;50(6):2522-2532. doi: 10.1007/s00261-024-04732-8. Epub 2024 Dec 4.
2
Intrahepatic cholangiocarcinoma: role of imaging as a critical component for multi-disciplinary treatment approach.肝内胆管癌：影像学作为多学科治疗方法关键组成部分的作用
Abdom Radiol (NY). 2025 Mar 17. doi: 10.1007/s00261-025-04856-5.
3
Differential diagnosis of hepatocellular carcinoma and intrahepatic cholangiocarcinoma based on spatial and channel attention mechanisms.基于空间和通道注意力机制的肝细胞癌与肝内胆管癌的鉴别诊断
J Cancer Res Clin Oncol. 2023 Sep;149(12):10161-10168. doi: 10.1007/s00432-023-04935-4. Epub 2023 Jun 2.
4
Cholangiocarcinoma: morphologic classification according to growth pattern and imaging findings.胆管癌：根据生长模式和影像学表现的形态学分类
AJR Am J Roentgenol. 2003 Sep;181(3):819-27. doi: 10.2214/ajr.181.3.1810819.
5
Cross-Sectional Imaging of Intrahepatic Cholangiocarcinoma: Development, Growth, Spread, and Prognosis.肝内胆管细胞癌的横断面成像：发展、生长、扩散和预后。
AJR Am J Roentgenol. 2017 Aug;209(2):W64-W75. doi: 10.2214/AJR.16.16923. Epub 2017 Jun 1.
6
Contrast-enhanced ultrasound for diagnosing subtypes of intrahepatic cholangiocarcinoma: a comparative study with poorly differentiated hepatocellular carcinoma.超声造影诊断肝内胆管癌亚型：与低分化肝细胞癌的对比研究
Cancer Imaging. 2025 Aug 27;25(1):107. doi: 10.1186/s40644-025-00923-8.
7
Varying appearances of cholangiocarcinoma: radiologic-pathologic correlation.胆管癌的不同表现：放射学与病理学的相关性
Radiographics. 2009 May-Jun;29(3):683-700. doi: 10.1148/rg.293085729.
8
Mass-forming intrahepatic cholangiocarcinoma presenting tumor growth in extrahepatic bile duct and superficial spreading.肿块形成型肝内胆管癌表现为肝外胆管肿瘤生长及浅表扩散。
Hepatogastroenterology. 2003 Jan-Feb;50(49):21-3.
9
Contrast-enhanced ultrasound imaging characteristics of intrahepatic cholangiocarcinoma with actionable gene variants detected by comprehensive cancer gene panel testing.经全面癌症基因检测板检测出具有可操作基因变异的肝内胆管癌的超声造影成像特征
Int J Clin Oncol. 2025 May 5. doi: 10.1007/s10147-025-02767-5.
10
CPZ: A Highly Sensitive Diagnostic Biomarker for the Differentiation Between Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma, Particularly in Poorly Differentiated Hepatocellular Carcinoma.CPZ：一种用于区分肝细胞癌和肝内胆管癌的高敏诊断生物标志物，尤其适用于低分化肝细胞癌。
Am J Surg Pathol. 2025 Jul 1;49(7):711-729. doi: 10.1097/PAS.0000000000002393. Epub 2025 Apr 7.

引用本文的文献

1
Prediction of PD-L1 expression and prognosis of mass-forming intrahepatic cholangiocarcinoma based on preoperative magnetic resonance imaging.基于术前磁共振成像预测肿块型肝内胆管癌的PD-L1表达及预后
Quant Imaging Med Surg. 2025 Aug 1;15(8):6822-6837. doi: 10.21037/qims-24-2130. Epub 2025 Jul 30.
2
MRI findings of confluent hepatic fibrosis caused by different etiologies.不同病因所致融合性肝纤维化的磁共振成像表现
BMC Gastroenterol. 2025 Jul 10;25(1):512. doi: 10.1186/s12876-025-04101-9.
3
Association between ultrasound-based biliary and parenchymal intrahepatic mass-forming cholangiocarcinoma subtypes and clinicopathological features and survival.

本文引用的文献

1
Preoperative subcategorization based on magnetic resonance imaging in intrahepatic cholangiocarcinoma.术前基于磁共振成像的肝内胆管细胞癌的亚分类。
Cancer Imaging. 2023 Feb 13;23(1):15. doi: 10.1186/s40644-023-00533-2.
2
Effect of FGFR2 Alterations on Overall and Progression-Free Survival in Patients Receiving Systemic Therapy for Intrahepatic Cholangiocarcinoma.成纤维细胞生长因子受体 2 改变对接受系统治疗的肝内胆管癌患者总生存期和无进展生存期的影响。
Target Oncol. 2022 Sep;17(5):517-527. doi: 10.1007/s11523-022-00906-w. Epub 2022 Sep 17.
3
Subtype Classification of Intrahepatic Cholangiocarcinoma Using Liver MR Imaging Features and Its Prognostic Value.
基于超声的肝内胆管和实质型肿块形成性胆管癌亚型与临床病理特征及生存之间的关联
Insights Imaging. 2025 Jun 19;16(1):130. doi: 10.1186/s13244-025-02019-0.
利用肝脏磁共振成像特征对肝内胆管癌进行亚型分类及其预后价值
Liver Cancer. 2022 Mar 30;11(3):233-246. doi: 10.1159/000521747. eCollection 2022 Jun.
4
Impact of FGFR2 gene fusions on survival of patients with intrahepatic cholangiocarcinoma following curative intent resection.成纤维细胞生长因子受体 2 基因融合对根治性切除术后肝内胆管癌患者生存的影响。
HPB (Oxford). 2022 Oct;24(10):1748-1756. doi: 10.1016/j.hpb.2022.05.1341. Epub 2022 May 28.
5
Genetic, Clinicopathological, and Radiological Features of Intrahepatic Cholangiocarcinoma with Ductal Plate Malformation Pattern.具有胆管板畸形模式的肝内胆管细胞癌的遗传、临床病理和影像学特征。
Gut Liver. 2022 Jul 15;16(4):613-624. doi: 10.5009/gnl210174. Epub 2021 Nov 23.
6
Mucin-producing Cystic Hepatobiliary Neoplasms: Updated Nomenclature and Clinical, Pathologic, and Imaging Features.黏液产生型胆胰管上皮肿瘤：最新命名法与临床、病理和影像学特征。
Radiographics. 2021 Oct;41(6):1592-1610. doi: 10.1148/rg.2021210011.
7
Lymphoepithelioma-like Intrahepatic Cholangiocarcinoma Is a Distinct Entity With Frequent pTERT/TP53 Mutations and Comprises 2 Subgroups Based on Epstein-Barr Virus Infection.淋巴上皮瘤样肝内胆管癌是一种独特的实体肿瘤，具有频繁的 pTERT/TP53 突变，并根据 Epstein-Barr 病毒感染分为 2 个亚组。
Am J Surg Pathol. 2021 Oct 1;45(10):1409-1418. doi: 10.1097/PAS.0000000000001716.
8
An overview of hepatocellular carcinoma with atypical enhancement pattern: spectrum of magnetic resonance imaging findings with pathologic correlation.具有非典型强化模式的肝细胞癌概述：磁共振成像表现谱与病理对照
Radiol Oncol. 2021 Jan 29;55(2):130-143. doi: 10.2478/raon-2021-0004.
9
Hepatic Mucinous Cystic Neoplasm Versus Simple Biliary Cyst: Assessment of Distinguishing Imaging Features Using CT and MRI.肝黏液性囊性肿瘤与单纯性胆管囊肿的 CT 和 MRI 鉴别诊断特征评估。
AJR Am J Roentgenol. 2021 Feb;216(2):403-411. doi: 10.2214/AJR.20.22768. Epub 2020 Dec 23.
10
Distinct clinical and prognostic implication of IDH1/2 mutation and other most frequent mutations in large duct and small duct subtypes of intrahepatic cholangiocarcinoma.IDH1/2 突变和其他常见突变在大导管型和小导管型肝内胆管细胞癌中的不同临床和预后意义。
BMC Cancer. 2020 Apr 15;20(1):318. doi: 10.1186/s12885-020-06804-6.