Villablanca J R, Burgess J W, Olmstead C E
Behav Brain Res. 1986 Mar;19(3):205-26. doi: 10.1016/0166-4328(86)90021-5.
Cats with removal of the left hemitelencephalon (hemispherectomy) as neonates (n = 12) or in adulthood (n = 14), were compared using a battery of 16 neurological and behavioral tests given when they were young adults (kittens) or at least 5 months after the lesion (adults). The neonatal-lesioned subjects grew normally and performed markedly and significantly better than adult-lesioned cats in 13 tests covering the wide range of movement, posture and sensory functions which were assessed. None of the animals recovered tactile placing of the right forelimb or a normal vision in the right visual field. However, the overall recovery was outstanding for all cats such that the neonatal-lesioned were hard to differentiate from intact controls in their spontaneous, daily activities. Because the lesions were similar in the two age-at-lesion groups, and since numerous functions were followed for prolonged, comparable postlesion time, we conclude that, after hemispherectomy in the cat, there definitely is greater functional recovery if the lesion is sustained early in life. We propose that the enhanced recovery of function in neonatal-lesioned cats is largely due to the extensive anatomical reorganization which we have demonstrated in ongoing studies, and which contrasts with a lesser remodeling in adult-lesioned cats.
对12只新生时（n = 12）或成年期（n = 14）接受左侧大脑半球切除术（hemispherectomy）的猫，在其处于青年期（小猫）或损伤后至少5个月（成年猫）时，使用一组16项神经学和行为学测试进行比较。在涵盖广泛运动、姿势和感觉功能评估的13项测试中，新生期损伤的受试者生长正常，且表现明显优于成年期损伤的猫。没有一只动物恢复右前肢的触觉放置或右视野的正常视力。然而，所有猫的总体恢复情况都很出色，以至于新生期损伤的猫在其自发的日常活动中很难与完整对照组区分开来。由于两个损伤年龄组的损伤情况相似，且由于在损伤后的较长可比时间内对众多功能进行了跟踪，我们得出结论，在猫进行半球切除术后，如果损伤发生在生命早期，功能恢复肯定会更好。我们认为，新生期损伤的猫功能恢复增强主要是由于我们在正在进行的研究中所证明的广泛解剖学重组，这与成年期损伤的猫较少的重塑形成对比。
