治疗抽动症的毒素：基于登记的自然主义研究为临床医生提供的实用指南。
Toxin for Tics: Practical Guidance for Clinicians from a Registry-Based Naturalistic Study.
作者信息
Pringsheim Tamara, Martino Davide
机构信息
Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
出版信息
Mov Disord Clin Pract. 2025 Mar;12(3):353-357. doi: 10.1002/mdc3.14296. Epub 2024 Dec 7.
BACKGROUND
Botulinum toxin is a recommended treatment for tics. There is little practical guidance on the use of this treatment.
OBJECTIVES
Our aim is to describe our experience using botulinum toxin injections for tics in adults. We provide information on tics treated, muscles injected, and dosages used to give practical guidance.
METHODS
We analyzed data from the Calgary Adult Tic Registry on tic severity, the tics and muscles injected, and dosages. We assessed treatment length, reasons for discontinuation, and concurrent medications.
RESULTS
Botulinum toxin was the most used medication for tics, received by 32 of 95 (33.7%) registry participants. Participants receiving botulinum toxin were significantly older and had significantly lower vocal tic severity and total tic severity. The most common motor tics treated were blinking, head turns, and shoulder raising. The mean length of treatment was 40.4 months.
CONCLUSIONS
Botulinum toxin is an effective and well-tolerated treatment for adults with tics.
背景
肉毒杆菌毒素是治疗抽动症的推荐疗法。关于该疗法的使用，实际指导较少。
目的
我们的目的是描述我们使用肉毒杆菌毒素注射治疗成人抽动症的经验。我们提供有关所治疗的抽动症、注射的肌肉以及所用剂量的信息，以提供实际指导。
方法
我们分析了卡尔加里成人抽动症登记处关于抽动严重程度、注射的抽动症和肌肉以及剂量的数据。我们评估了治疗时长、停药原因和同时使用的药物。
结果
肉毒杆菌毒素是治疗抽动症最常用的药物，95名登记参与者中有32人（33.7%）使用了该药物。接受肉毒杆菌毒素治疗的参与者年龄显著更大，发声抽动严重程度和抽动症总严重程度显著更低。最常治疗的运动性抽动是眨眼、转头和耸肩。平均治疗时长为40.4个月。
结论
肉毒杆菌毒素是治疗成人抽动症的一种有效且耐受性良好的疗法。
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