Odebeatu Chinonso Christian, Darssan Darsy, Revez Joana A, Roscoe Charlotte, Do Phu, Reid Simon, Osborne Nicholas J
School of Public Health, The University of Queensland, Herston, Brisbane, QLD, Australia.
Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia.
Int J Hyg Environ Health. 2025 Mar;264:114502. doi: 10.1016/j.ijheh.2024.114502. Epub 2024 Dec 6.
Exposure to greenspace is associated with positive health outcomes. This relationship is poorly understood, with limited knowledge on the mechanisms through which greenspace affects health, including biomarkers of greenspace effects.
We used data from the UK Biobank to examine the cross-sectional association between greenspace exposure and serum 25-hydroxyvitamin D [25(OH)D]. Greenspace was assessed in a 300- and 1000-m buffer of land cover around each participant's home location, while 25(OH)D was measured by chemiluminescent immunoassay. We used multinomial regression models accounting for individual and area-level covariates. Additionally, we conducted mediation analysis by physical activity and time spent outdoors and performed various stratifications and sensitivity analyses.
A total of 443 810 participants (mean age: 56.51 [SD: 8.1] years, 53.6% females) were included in the study. Compared to the first quartile (within 1000 m buffer of participants' home locations), we found positive associations between the highest quartile of greenspace and insufficient (OR: 1.16, 95% CI: 1.11, 1.21) and sufficient 25(OH)D (OR: 1.36, 95% CI: 1.30, 1.42) categories after adjusting for individual- and areal-level covariates. Other quartiles showed similar but smaller effect estimates. The observed association exhibited similar directionality when a 300 m buffer was used, and was more pronounced among males, and most deprived individuals. Physical activity and time spent outdoors partially explained the relationship between greenspace quartiles and sufficient serum 25(OH)D.
We found positive associations between greenspace quartiles and serum 25(OH)D categories. This has implications for greening policies aimed at reducing vitamin D deficiency through controlled sun exposure.
接触绿地与积极的健康结果相关。这种关系目前了解甚少，对于绿地影响健康的机制，包括绿地效应的生物标志物，所知有限。
我们使用了英国生物银行的数据来研究绿地暴露与血清25-羟基维生素D [25(OH)D]之间的横断面关联。在每个参与者家庭住址周围300米和1000米的土地覆盖缓冲区内评估绿地情况，而25(OH)D通过化学发光免疫分析法进行测量。我们使用了考虑个体和区域层面协变量的多项回归模型。此外，我们通过身体活动和户外停留时间进行中介分析，并进行了各种分层和敏感性分析。
共有443810名参与者（平均年龄：56.51 [标准差：8.1]岁，53.6%为女性）纳入研究。与第一四分位数（参与者家庭住址1000米缓冲区内）相比，在调整个体和区域层面协变量后，我们发现绿地最高四分位数与25(OH)D不足（比值比：1.16，95%置信区间：1.11，1.21）和充足（比值比：1.36，95%置信区间：1.30，1.42）类别之间存在正相关。其他四分位数显示出类似但较小的效应估计值。当使用300米缓冲区时，观察到的关联呈现相似的方向性，且在男性和最贫困个体中更为明显。身体活动和户外停留时间部分解释了绿地四分位数与血清25(OH)D充足之间的关系。
我们发现绿地四分位数与血清25(OH)D类别之间存在正相关。这对于旨在通过控制阳光照射来减少维生素D缺乏的绿化政策具有启示意义。
