Rockliffe Alice, Wheeler Lauren, Lidhar Kiran, Dhar Arun, Pemberton Michelle, Kasprowicz Richard, Hopely Ceridwen, Francis Jo, Marine Shane, Brierley David, Suckling Lorna
Discovery Biology & Screening, GSK R&D, Stevenage, Hertfordshire, UK.
PerkinElmer, Stevenage, Hertfordshire, UK.
SLAS Technol. 2025 Feb;30:100230. doi: 10.1016/j.slast.2024.100230. Epub 2024 Dec 5.
At GSK, we have implemented custom integrated robotics platforms housed in bespoke biosafety enclosures to augment our capabilities in advanced cellular screening. Here we present and discuss the impact of one such system, the Cellular Automated Screening Platform (CASPer). We evaluate the benefits of implementing specific processes on CASPer that include increasing the throughput of safety screening assays and improving data integrity when testing complex in vitro 3D primary human hepatocyte models. This article provides an overview of the platforms installed and offers insight into their utilisation by presenting example workflows and quality control solutions which have been implemented. We offer perspective on the advantages of such custom integrated systems and their limitations in cellular screening for early drug discovery.
在葛兰素史克公司，我们已实施了定制的集成机器人平台，这些平台置于定制的生物安全罩内，以增强我们在先进细胞筛选方面的能力。在此，我们展示并讨论其中一个这样的系统——细胞自动筛选平台（CASPer）的影响。我们评估了在CASPer上实施特定流程的益处，这些流程包括提高安全筛选试验的通量以及在测试复杂的体外3D原代人肝细胞模型时改善数据完整性。本文概述了已安装的平台，并通过展示已实施的示例工作流程和质量控制解决方案，深入了解了它们的使用情况。我们对这类定制集成系统的优势及其在早期药物发现细胞筛选中的局限性提供了观点。
