Shah M V, Jones D I, Rosen M
Br J Anaesth. 1986 May;58(5):508-11. doi: 10.1093/bja/58.5.508.
A randomized, double-blind, placebo-controlled study of buprenorphine was carried out in 20 patients after cholecystectomy. The drug was given on "patient demand" either i.m. (0.15 mg) or sublingually (0.2 mg) with a minimum dose interval of 30 min. Over the 24-h study period the mean demand by the sublingual route was 0.8 mg (range 0.6-1.2 mg) and by the i.m. route 0.66 mg (range 0.45-0.9 mg). Pain relief, by visual analogue scales and grading, was similar. Plasma buprenorphine concentrations varied more after sublingual administration. Either route was effective for the treatment of pain when administered by "patient demand".
对20例胆囊切除术后患者进行了一项关于丁丙诺啡的随机、双盲、安慰剂对照研究。药物根据“患者需求”给予，肌内注射（0.15毫克）或舌下含服（0.2毫克），最小给药间隔为30分钟。在24小时的研究期间，舌下给药途径的平均需求量为0.8毫克（范围0.6 - 1.2毫克），肌内注射途径为0.66毫克（范围0.45 - 0.9毫克）。通过视觉模拟评分和分级评估，疼痛缓解情况相似。舌下给药后血浆丁丙诺啡浓度变化更大。当根据“患者需求”给药时，两种途径对疼痛治疗均有效。
