Harmer M, Slattery P J, Rosen M, Vickers M D
Br J Anaesth. 1983 Jan;55(1):21-5. doi: 10.1093/bja/55.1.21.
A double-blind comparison between buprenorphine and pentazocine was performed in 20 patients using an on demand analgesic system to provide analgesia after operation. The quality of analgesia, assessed subjectively, was good with both drugs and drug consumptions were compatible with previous potency estimates. The mean doses demanded in 24 h of buprenorphine (1.68 mg) and of pentazocine (382 mg) are consistent with those found in other trials although the between-patient variation was five- or six-fold. There was no significant difference in side-effects between the two groups. Buprenorphine and pentazocine may be used successfully in an on demand system to provide relief of severe pain after operation.
采用按需镇痛系统对20例患者进行了丁丙诺啡和喷他佐辛的双盲比较，以提供术后镇痛。主观评估的镇痛质量在两种药物中均良好，药物消耗量与先前的效价估计相符。丁丙诺啡（1.68毫克）和喷他佐辛（382毫克）24小时内的平均需求量与其他试验结果一致，尽管患者之间的差异为五到六倍。两组之间的副作用无显著差异。丁丙诺啡和喷他佐辛可成功用于按需给药系统，以缓解术后剧痛。
