Liu Fangqing, Yin Xiaoshan
Clinical Psychology, The University of Edinburgh School of Health in Social Science, Edinburgh, UK
Clinical Psychology, The University of Edinburgh School of Health in Social Science, Edinburgh, UK.
BMJ Open. 2024 Aug 31;14(8):e083896. doi: 10.1136/bmjopen-2024-083896.
Intermittent explosive disorder (IED) is characterised by recurrent, sudden episodes of impulsive aggression that are disproportionate to the provocation. The condition's management remains challenging due to the variability in treatment efficacy and the absence of Food and Drug Administration-approved interventions specifically for IED. This meta-analysis aims to evaluate the effectiveness of existing treatments for IED.
Adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a comprehensive literature search was conducted in November 2023, yielding 17 randomised controlled trials after screening and eligibility assessments. Studies were included based on participants' confirmed diagnosis of IED, sufficient statistical power and provision of data for effect size calculation. Interventions analysed included pharmacological treatments, psychotherapies and combination therapies, with an emphasis on cognitive-behavioural therapy and selective serotonin reuptake inhibitors. Quality assessment was performed using the Cochrane Risk of Bias Tool.
Given that our study is a synthesis of published data, ethical approval from a research ethics committee is not required. Nevertheless, the methodology of this review was designed to ensure full transparency and accountability. All efforts have been made to respect the confidentiality and intellectual property rights of the original data sources. Any ethical issues encountered during the data collection process were addressed in accordance with the guidelines of the Declaration of Helsinki. As this research involves the analysis of existing published data, there are no direct safety concerns related to patient interactions. Our primary focus has been on ensuring the secure handling and processing of data to uphold the ethical standards set by previous original studies. To ensure the findings of our meta-analysis reach both the academic community and the public effectively, we aim to submit our findings to peer-reviewed journals within the fields of psychology to ensure rigorous review and broad academic dissemination.
CRD42024497587.
间歇性爆发性障碍（IED）的特征是反复出现、突然发作的冲动性攻击行为，其程度与挑衅不相称。由于治疗效果的差异以及缺乏美国食品药品监督管理局专门批准用于治疗IED的干预措施，该疾病的管理仍然具有挑战性。本荟萃分析旨在评估现有治疗方法对IED的有效性。
遵循系统评价和荟萃分析的首选报告项目指南，于2023年11月进行了全面的文献检索，经过筛选和资格评估后得到17项随机对照试验。纳入的研究基于参与者确诊为IED、足够的统计效力以及提供效应量计算的数据。分析的干预措施包括药物治疗、心理治疗和联合治疗，重点是认知行为疗法和选择性5-羟色胺再摄取抑制剂。使用Cochrane偏倚风险工具进行质量评估。
鉴于我们的研究是已发表数据的综合，无需研究伦理委员会的伦理批准。然而，本综述的方法旨在确保完全透明和可问责性。已尽一切努力尊重原始数据源的保密性和知识产权。数据收集过程中遇到的任何伦理问题均按照《赫尔辛基宣言》的指南处理。由于本研究涉及对现有已发表数据的分析，与患者互动不存在直接安全问题。我们的主要重点是确保数据的安全处理和加工，以维护先前原始研究设定的伦理标准。为确保我们荟萃分析的结果有效传达给学术界和公众，我们旨在将研究结果提交给心理学领域的同行评审期刊，以确保严格评审和广泛的学术传播。
CRD42024497587。
