Olvera Rene L
Division of Child and Adolescent Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78284-7792, USA.
CNS Drugs. 2002;16(8):517-26. doi: 10.2165/00023210-200216080-00002.
Intermittent explosive disorder (IED) is characterised by discrete episodes of aggressive impulses that result in serious assaultive acts towards people or destruction of property. IED causes severe impairments in daily function. The diagnosis of IED should be made only after a thorough medical work-up. A structured or semi-structured diagnostic interview is helpful to ensure that comorbid and pre-existing conditions are considered. There is a lack of controlled trials of agents for the treatment of patients with IED, but there is evidence that mood stabilisers, antipsychotics, beta-blockers, alpha(2)-agonists, phenytoin and antidepressants may be useful. Behavioural interventions may be valuable as part of the overall treatment of IED.
间歇性爆发性障碍（IED）的特征是具有攻击性冲动的离散发作，这些发作会导致对他人的严重攻击行为或财产破坏。IED会导致日常功能严重受损。IED的诊断应仅在全面的医学检查之后进行。结构化或半结构化的诊断访谈有助于确保考虑到共病和既往存在的状况。目前缺乏针对IED患者治疗药物的对照试验，但有证据表明心境稳定剂、抗精神病药、β受体阻滞剂、α₂激动剂、苯妥英和抗抑郁药可能有用。行为干预作为IED整体治疗的一部分可能具有重要价值。
