多发性骨髓瘤患者血清中本-周蛋白的发生率及其可能的相关性。

The incidence and possible relevance of Bence-Jones protein in the sera of patients with multiple myeloma.

作者信息

Sinclair D, Dagg J H, Smith J G, Stott D I

出版信息

Br J Haematol. 1986 Apr;62(4):689-94. doi: 10.1111/j.1365-2141.1986.tb04092.x.

DOI:10.1111/j.1365-2141.1986.tb04092.x

Abstract

We present results showing that the detectable incidence of Bence-Jones protein in the sera of patients with multiple myeloma is equivalent to the highest detectable incidence of Bence-Jones protein in highly concentrated urine when tested by immuno-isoelectric focusing. In a series of 25 multiple myeloma patients, immuno-isoelectric focusing showed the incidence of Bence-Jones proteinemia to be 68% compared with a detectable incidence of Bence-Jones proteinuria of 32-64% by immunoelectrophoresis and immuno-isoelectric focusing depending upon the urine concentration factor. In view of the variability of factors governing urinary Bence-Jones protein levels, such as renal catabolism, reabsorption and losses during concentration, we suggest that monitoring of serum Bence-Jones protein by immuno-isoelectric focusing should be carried out in conjunction with measurements of urinary Bence-Jones protein in multiple myeloma.

摘要

我们展示的结果表明，通过免疫等电聚焦检测，多发性骨髓瘤患者血清中本-周蛋白的可检测发生率与高浓缩尿液中本-周蛋白的最高可检测发生率相当。在一系列25例多发性骨髓瘤患者中，免疫等电聚焦显示本-周蛋白血症的发生率为68%，而根据尿液浓缩系数，免疫电泳和免疫等电聚焦检测到的本-周蛋白尿的发生率为32%-64%。鉴于影响尿中本-周蛋白水平的因素存在变异性，如肾脏分解代谢、重吸收以及浓缩过程中的损失，我们建议在多发性骨髓瘤患者中，应结合尿本-周蛋白的检测，通过免疫等电聚焦对血清本-周蛋白进行监测。