Takeshita A, Imamura T
Jpn Circ J. 1986 Jul;50(7):671-4. doi: 10.1253/jcj.50.671.
We examined whether digitalis augments cardiopulmonary baroreflex control of forearm vascular resistance in normal young men. Cardiopulmonary baroreceptor input was reduced with lower body negative pressure (LBNP) at 10 and 20 mmHg which decreased central venous pressure (CVP) but did not alter blood pressure (BP) or heart rate (HR). Decreases in forearm blood flow and increases in forearm vascular resistance with LBNP were greater after cedilanid than before and the slope of the regression line relating changes in central venous pressure and those in forearm vascular resistance was steeper after cedilanid. Vasoconstrictor responses to a cold pressor test did not differ before and after cedilanid, which suggested that augmented responses to LBNP after cedilanid were not due to a generalized change in reflex control. These results suggest that cedilaniid augments the tonic inhibitory influence of cardiopulmonary baroreceptors in normal men.
我们研究了洋地黄是否能增强正常青年男性心肺压力反射对前臂血管阻力的控制。通过10和20mmHg的下体负压（LBNP）降低心肺压力感受器输入，这降低了中心静脉压（CVP），但未改变血压（BP）或心率（HR）。西地兰给药后，LBNP引起的前臂血流量减少和前臂血管阻力增加比给药前更大，且中心静脉压变化与前臂血管阻力变化之间的回归线斜率在西地兰给药后更陡。西地兰给药前后对冷加压试验的血管收缩反应无差异，这表明西地兰给药后对LBNP反应增强并非由于反射控制的普遍变化。这些结果表明，西地兰增强了正常男性心肺压力感受器的紧张性抑制作用。
