He Zhimin, Fan Gongduan, Xu Zongqiong, Wu Shiyun, Xie Jiankun, Qiang Wei, Xu Kai-Qin
College of Civil Engineering, Fuzhou University, 350116, Fujian, China.
College of Civil Engineering, Fuzhou University, 350116, Fujian, China; Fujian Provincial Key Laboratory of Electrochemical Energy Storage Materials, Fuzhou University, 350002, Fujian, China.
Bioresour Technol. 2025 Feb;418:131950. doi: 10.1016/j.biortech.2024.131950. Epub 2024 Dec 6.
Anaerobic ammonia oxidation (anammox), an energy-efficient technology for treating ammonium-rich wastewater, faces the challenge of antibiotic stress in sewage. This paper systematically evaluated the impact of antibiotics on anammox by considering both inhibitory effects and recovery duration. This review focused on cellular responses, including extracellular polymeric substances (EPS), quorum sensing (QS), and enzymes. Then, the physiological properties of cells and the interactions between nitrogen and carbon metabolism under antibiotic stress were discussed, particularly within the anammoxosome. The microbial community evolution and the development and transfer of antibiotic resistance genes (ARGs) were further analyzed to reveal the resistance mechanisms of anammox. To address the limitations imposed by antibiotics, the development of bio-augmentation and combined processes based on molecular biology techniques, such as bio-electrochemical systems (BES), has been suggested. This review offered new insights into the mechanisms of antibiotic inhibition during the anammox process and aimed to advance their engineering applications.
厌氧氨氧化（anammox）是一种处理高氨氮废水的节能技术，但面临着污水中抗生素胁迫的挑战。本文通过考虑抑制作用和恢复持续时间，系统评估了抗生素对厌氧氨氧化的影响。本综述聚焦于细胞反应，包括胞外聚合物（EPS）、群体感应（QS）和酶。然后，讨论了抗生素胁迫下细胞的生理特性以及氮和碳代谢之间的相互作用，特别是在厌氧氨氧化体内部。进一步分析了微生物群落演变以及抗生素抗性基因（ARGs）的产生和转移，以揭示厌氧氨氧化的抗性机制。为解决抗生素带来的限制，有人提出基于分子生物学技术开发生物强化和联合工艺，如生物电化学系统（BES）。本综述为厌氧氨氧化过程中抗生素抑制机制提供了新见解，旨在推动其工程应用。
