膳食脂肪质量指数与糖尿病前期及2型糖尿病风险：德黑兰脂质与葡萄糖研究

Dietary fat quality indices and risk of pre-diabetes and type 2 diabetes mellitus: Tehran Lipid and Glucose Study.

作者信息

Gaeini Zahra, Alvirdizadeh Sevda, Hosseinpour-Niazi Somayeh, Mirmiran Parvin, Azizi Fereidoun

机构信息

Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Public Health Nutr. 2024 Dec 9;28(1):e8. doi: 10.1017/S1368980024001216.

DOI:10.1017/S1368980024001216

PMID:39647851

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11736655/

Abstract

OBJECTIVE

To assess associations between dietary fat quality indices and risk of pre-diabetes and type 2 diabetes mellitus (T2DM) among Iranian adults.

DESIGN

Daily intakes of fatty acids were estimated using a validated FFQ with 168 food items. Adjusted hazard ratios (HR) and 95 % CI for pre-diabetes and T2DM were calculated across tertile categories of dietary fat quality indices including the atherogenic index, thrombogenic index, health-promoting index, ratio of PUFA to SFA (PUFA:SFA) and ratio of hypo- and hypercholesterolaemia (h:H).

SETTING

Tehran Lipid and Glucose Study.

PARTICIPANTS

Iranian men and women.

RESULTS

The mean (sd) age of the 2042 pre-diabetes-free participants in pre-diabetes analysis was 38·84 (12·97), and 55·2 % were women. In T2DM analysis, the mean (sd) age of the 2295 T2DM-free participants was 40·06 (13·42), and 54·6 % of them were women. In the crude model, the PUFA:SFA ratio was positively associated with T2DM incidence (HR = 1·43; 95 % CI 1·04, 1·98). However, after adjustment for confounding variables, there were no significant associations between dietary fat quality indices and risk of pre-diabetes and T2DM.

CONCLUSIONS

We found no significant association between fat quality indices and risk of pre-diabetes and T2DM. Further prospective and clinical trial studies are needed to clarify the issue.

摘要

目的

评估伊朗成年人饮食脂肪质量指数与糖尿病前期及2型糖尿病（T2DM）风险之间的关联。

设计

使用包含168种食物的有效食物频率问卷（FFQ）估算脂肪酸的每日摄入量。计算饮食脂肪质量指数（包括致动脉粥样硬化指数、血栓形成指数、健康促进指数、多不饱和脂肪酸与饱和脂肪酸比值（PUFA:SFA）以及低胆固醇血症与高胆固醇血症比值（h:H））三分位数类别中糖尿病前期和T2DM的校正风险比（HR）及95%置信区间（CI）。

地点

德黑兰血脂与血糖研究。

参与者

伊朗男性和女性。

结果

糖尿病前期分析中2042名无糖尿病前期参与者的平均（标准差）年龄为38.84（12.97）岁，55.2%为女性。在T2DM分析中，2295名无T2DM参与者的平均（标准差）年龄为40.06（13.42）岁，其中54.6%为女性。在粗模型中，PUFA:SFA比值与T2DM发病率呈正相关（HR = 1.43；95%CI 1.04，1.98）。然而，在对混杂变量进行调整后，饮食脂肪质量指数与糖尿病前期和T2DM风险之间无显著关联。