Kem D C, Tang K, Hanson C S, Brown R D, Painton R, Weinberger M H, Hollifield J W
J Clin Endocrinol Metab. 1985 Jan;60(1):67-73. doi: 10.1210/jcem-60-1-67.
Serum 18-hydroxycorticosterone, aldosterone, and potassium were measured under basal conditions in 34 patients with documented primary aldosteronism, 10 patients with essential hypertension, and 9 normal subjects. The results revealed that 22 of 23 patients with aldosterone-producing adenomas had 18-hydroxycorticosterone levels greater than 100 ng/dl, and all 9 patients with idiopathic adrenal hyperplasia had plasma levels less than 100 ng/dl. Two patients with unusual macromicronodular hyperplasia of the adrenal glands had levels greater than 100 ng/dl. We found a significant relationship between serum potassium and the ratio of 18-hydroxycorticosterone to aldosterone in patients with idiopathic adrenal hyperplasia, but not in those with an aldosterone-producing adenoma. We conclude that measurement of serum 18-hydroxycorticosterone is a useful predictor of the etiology of primary aldosteronism.
在基础条件下，对34例确诊为原发性醛固酮增多症的患者、10例原发性高血压患者和9名正常受试者测定了血清18 - 羟皮质酮、醛固酮和钾。结果显示，23例醛固酮分泌腺瘤患者中有22例18 - 羟皮质酮水平高于100 ng/dl，9例特发性肾上腺增生患者的血浆水平均低于100 ng/dl。2例肾上腺有不寻常的大结节增生患者的水平高于100 ng/dl。我们发现，特发性肾上腺增生患者的血清钾与18 - 羟皮质酮与醛固酮的比值之间存在显著关系，而醛固酮分泌腺瘤患者则无此关系。我们得出结论，测定血清18 - 羟皮质酮是原发性醛固酮增多症病因的有用预测指标。
