Kapoor Gauri, Prakash Swati, Jaiswal Vishakha, Singh Ashok K
Amity Institute of Pharmacy, Lucknow, Amity University Uttar Pradesh, Noida, Uttar Pradesh, India.
Cancer Invest. 2025 Jan;43(1):1-23. doi: 10.1080/07357907.2024.2437614. Epub 2024 Dec 8.
Recent research has underscored the pivotal role of chronic inflammation in cancer development. Investigations have elucidated key molecular mechanisms underpinning inflammation-related cancer. Extrinsic pathway, driven by inflammatory conditions and intrinsic pathway, propelled by genetic events, emerged as critical links between inflammation and carcinogenesis. The persistent inflammation exacerbates genomic instability, providing a mechanistic link between inflammation and cancer. Targeting crucial inflammatory pathways such as NFκB, JAK-STAT, MAPK/ERK, PI3K/AKT, Wnt and TGF-β, holds promise for advancing cancer treatment modalities. Hence, understanding the key signalling pathways will highlight the intricate interplay between inflammation and cancer recognizing it as a potential target for interventions.
近期研究强调了慢性炎症在癌症发展中的关键作用。调查阐明了炎症相关癌症的关键分子机制。由炎症条件驱动的外在途径和由基因事件推动的内在途径，成为炎症与致癌作用之间的关键联系。持续性炎症加剧基因组不稳定，为炎症与癌症之间提供了一种机制联系。靶向关键炎症途径，如核因子κB（NFκB）、Janus激酶-信号转导子和转录激活子（JAK-STAT）、丝裂原活化蛋白激酶/细胞外信号调节激酶（MAPK/ERK）、磷脂酰肌醇-3激酶/蛋白激酶B（PI3K/AKT）、Wnt和转化生长因子-β（TGF-β），有望推进癌症治疗模式。因此，了解关键信号通路将突出炎症与癌症之间复杂的相互作用，将其视为干预的潜在靶点。
