Chi Hang, Wu Wei, Bao Hongxia, Wu Yingjie, Hu Narisu
Hard Tissue Development and Regeneration Laboratory, Harbin Medical University, Harbin, 150086, China.
Genomics Research Center, Key Laboratory of Gut Microbiota and Pharmacogenomics of Heilongjiang Province, State-Province Key Laboratory of Biomedicine-Pharmaceutics of China, College of Pharmacy, Harbin Medical University, Harbin, 150081, China.
Adv Healthc Mater. 2025 Apr;14(10):e2404303. doi: 10.1002/adhm.202404303. Epub 2024 Dec 8.
A self-propulsion Janus gallium (Ga)/magnesium (Mg) bimetallic micromotor is designed with favorable biocompatibility and antimicrobial properties as a therapeutic strategy for periodontitis. The Janus Ga/Mg micromotors are fabricated by microcontact printing technique to asymmetrically modify liquid metallic gallium onto magnesium microspheres. Hydrogen bubbles produced by the magnesium-water reaction can provide the driving performance of up to 31.03 µm s (pH 6.8), prompting the micromotor to actively breakthrough the biological barrier of saliva and gingival crevice fluid (GCF) into the bottom of periodontal pockets. In addition, the Janus Ga/Mg micromotors are effectively converted by degradation into the built-in antimicrobial ion Ga(III) to eliminate deep-seated Porphyromonas gingivalis (P.gingivalis), with bactericidal efficiencies of over 99.8%. The developed Janus Ga/Mg micromotors have demonstrated potent antimicrobial and anti-inflammatory activity both in vitro and in vivo studies. Crucially, it reduces alveolar bone resorption, demonstrating the superior efficacy of liquid metal gallium in treating periodontitis. Therefore, Ga/Mg bimetallic micromotors hold great promise to be an innovative and translational drug delivery system to treat periodontitis or other inflammation-related diseases in the near future.
设计了一种具有良好生物相容性和抗菌性能的自推进式Janus镓（Ga）/镁（Mg）双金属微电机，作为治疗牙周炎的一种策略。通过微接触印刷技术制备Janus Ga/Mg微电机，将液态金属镓不对称地修饰在镁微球上。镁与水反应产生的氢气泡可提供高达31.03 µm/s（pH 6.8）的驱动性能，促使微电机主动突破唾液和龈沟液（GCF）的生物屏障，进入牙周袋底部。此外，Janus Ga/Mg微电机通过降解有效地转化为内置抗菌离子Ga(III)，以消除深层牙龈卟啉单胞菌（P.gingivalis），杀菌效率超过99.8%。所开发的Janus Ga/Mg微电机在体外和体内研究中均显示出强大的抗菌和抗炎活性。至关重要的是，它减少了牙槽骨吸收，证明了液态金属镓在治疗牙周炎方面的卓越疗效。因此，Ga/Mg双金属微电机在不久的将来有望成为一种创新的、可转化的药物递送系统，用于治疗牙周炎或其他炎症相关疾病。
