Nakiranda Regina, Malan Linda, Ricci Hannah, Kruger Herculina S, Nienaber Arista, Visser Marina, Ricci Cristian, Faber Mieke, Smuts Cornelius M
Centre of Excellence for Nutrition, North-West University, Potchefstroom, South Africa.
Africa Unit for Transdisciplinary Health Research (AUTHeR), North-West University, Potchefstroom, South Africa.
Matern Child Nutr. 2025 Apr;21(2):e13782. doi: 10.1111/mcn.13782. Epub 2024 Dec 9.
This secondary analysis of the Eggcel-growth study investigated the effect of daily egg intake for 6 months in infants aged 6-9 months on environmental enteric dysfunction (EED) biomarkers and the association of EED markers with growth faltering. A randomised controlled trial was conducted in Jouberton, South Africa, among 500 infants randomly assigned equally to either an intervention group receiving a daily chicken egg or a control group. Both groups were followed up for 6 months. Data on infant and maternal sociodemographic information and anthropometric status of infants were collected. EED and inflammatory markers were analysed using Q-Plex Human EED (11-Plex) assay. There was a significant reduction in fibroblast growth factor 21 (FGF21) concentration in the intervention group (B = -0.132; 95% CI -0.255, -0.010; p = 0.035). Baseline, insulin-like growth factor 1 (IGF-1) was positively associated with endpoint length-for-age z-score (LAZ), weight-for-age z-score (WAZ) and weight-for-length z-score (WLZ) and there was an inverse relationship between baseline FGF21 and intestinal fatty acid-binding protein (I-FABP) with endpoint growth indicators. Baseline IGF-1 was positively associated with reduced odds of wasting, stunting and being underweight (p < 0.001) and baseline FGF21 was associated with increased odds of stunting (p = 0.002), wasting (p = 0.031) and being underweight (p = 0.035). There was a 20% increased odds of stunting with baseline I-FABP (p = 0.045) and a 30% increased odds of being underweight with baseline soluble CD14 (p = 0.039). Complementary feeding with eggs decreased growth hormone resistance (reduced FGF21 levels); however, FGF21 and I-FABP levels were linked to increased growth faltering. Trial Registration: ClinicalTrials.gov: NCT05168085.
这项对Eggcel生长研究的二次分析，调查了6至9个月大婴儿每日摄入鸡蛋6个月对环境肠道功能障碍（EED）生物标志物的影响，以及EED标志物与生长发育迟缓之间的关联。在南非的朱伯顿进行了一项随机对照试验，500名婴儿被随机平均分配到接受每日一个鸡蛋的干预组或对照组。两组均随访6个月。收集了婴儿和母亲的社会人口学信息以及婴儿的人体测量状况数据。使用Q-Plex Human EED（11-Plex）检测法分析EED和炎症标志物。干预组中，成纤维细胞生长因子21（FGF21）浓度显著降低（B = -0.132；95%置信区间 -0.255，-0.010；p = 0.035）。基线时，胰岛素样生长因子1（IGF-1）与年龄别身长Z评分（LAZ）、年龄别体重Z评分（WAZ）和身长别体重Z评分（WLZ）呈正相关，且基线FGF21和肠道脂肪酸结合蛋白（I-FABP）与终点生长指标呈负相关。基线IGF-1与消瘦、发育迟缓及体重不足几率降低呈正相关（p < 0.001），基线FGF21与发育迟缓几率增加相关（p = 0.002）、消瘦（p = 0.031）及体重不足（p = 0.035）。基线I-FABP使发育迟缓几率增加20%（p = 0.045），基线可溶性CD14使体重不足几率增加30%（p = 0.039）。鸡蛋辅食喂养降低了生长激素抵抗（FGF21水平降低）；然而，FGF21和I-FABP水平与生长发育迟缓增加有关。试验注册：ClinicalTrials.gov：NCT05168085。
