• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Selective loss of a family of gene transcripts in a hereditary murine cataract.

作者信息

Garber A T, Winkler C, Shinohara T, King C R, Inana G, Piatigorsky J, Gold R J

出版信息

Science. 1985 Jan 4;227(4682):74-7. doi: 10.1126/science.3964960.

DOI:10.1126/science.3964960
PMID:3964960
Abstract

The eye lens of the Fraser mouse contains a dominantly inherited cataract with reduced amounts of seven distinct but homologous gamma crystallins encoded by a family of gamma-crystallin genes. The results of experiments with cultured lenses, cell-free RNA translation, and Northern blot hybridization indicated a specific loss of the family of gamma-crystallin messenger RNA's in the Fraser mouse lens. Southern blot hybridization of genomic DNA's from normal and Fraser mice showed no differences in gamma-crystallin coding sequences.

摘要

相似文献

1
Selective loss of a family of gene transcripts in a hereditary murine cataract.
Science. 1985 Jan 4;227(4682):74-7. doi: 10.1126/science.3964960.
2
Persistence of crystallin messenger RNA's with reduced translation in hereditary cataracts in mice.晶状体蛋白信使核糖核酸在小鼠遗传性白内障中持续存在且翻译减少。
Science. 1980 Nov 21;210(4472):914-6. doi: 10.1126/science.7434006.
3
Reduced levels of gamma-crystallin transcripts during embryonic development of murine Cat2nop mutant lenses.在小鼠Cat2nop突变晶状体胚胎发育过程中γ-晶体蛋白转录本水平降低。
Graefes Arch Clin Exp Ophthalmol. 1995 Dec;233(12):795-800. doi: 10.1007/BF00184093.
4
Deficiency of functional messenger RNA for a developmentally regulated beta-crystallin polypeptide in a hereditary cataract.
Science. 1982 Jul 30;217(4558):463-4. doi: 10.1126/science.6178163.
5
Autophagy and UPR in alpha-crystallin mutant knock-in mouse models of hereditary cataracts.遗传性白内障α-晶体蛋白突变体敲入小鼠模型中的自噬与未折叠蛋白反应
Biochim Biophys Acta. 2016 Jan;1860(1 Pt B):234-9. doi: 10.1016/j.bbagen.2015.06.001. Epub 2015 Jun 11.
6
Crystallin mRNA concentrations and distribution in lens of normal and galactosemic rats. Implications in development of sugar cataracts.正常和半乳糖血症大鼠晶状体中晶状体蛋白mRNA的浓度及分布。对糖性白内障形成的影响。
Invest Ophthalmol Vis Sci. 1991 Apr;32(5):1638-47.
7
Multiple gamma-crystallins of the mouse lens: fractionation of mRNAs by cDNA cloning.小鼠晶状体的多种γ-晶体蛋白：通过cDNA克隆对mRNA进行分级分离。
Proc Natl Acad Sci U S A. 1982 May;79(9):2783-7. doi: 10.1073/pnas.79.9.2783.
8
Differential localization by in situ hybridization of specific crystallin transcripts during mouse lens development.
Differentiation. 1991 Aug;47(3):143-7. doi: 10.1111/j.1432-0436.1991.tb00232.x.
9
Differential regulation of gamma-crystallin genes during mouse lens development.小鼠晶状体发育过程中γ-晶状体蛋白基因的差异调控。
Dev Biol. 1987 Jan;119(1):260-7. doi: 10.1016/0012-1606(87)90227-2.
10
Cloning and mapping the mouse Crygs gene and non-lens expression of [gamma]S-crystallin.小鼠Crygs基因的克隆与定位以及γS-晶体蛋白的非晶状体表达
Mol Vis. 1998 Apr 30;4:8.

引用本文的文献

1
Assignment of congenital cataract Volkmann type (CCV) to chromosome 1p36.先天性白内障福尔克曼型（CCV）定位于染色体1p36。
Hum Genet. 1995 Jul;96(1):33-8. doi: 10.1007/BF00214183.
2
A locus for a human hereditary cataract is closely linked to the gamma-crystallin gene family.人类遗传性白内障的一个基因座与γ-晶状体蛋白基因家族紧密连锁。
Proc Natl Acad Sci U S A. 1987 Jan;84(2):489-92. doi: 10.1073/pnas.84.2.489.