Yuan Chao, Shentu Yuting, Ji Qiuhong
Department of Neurology, Nantong University, Nantong, China.
Department of Neurology, Affiliated Hospital of Nantong University, Nantong, China.
Front Aging Neurosci. 2024 Nov 22;16:1476913. doi: 10.3389/fnagi.2024.1476913. eCollection 2024.
The high incidence, death, disability, and recurrence of ischemic stroke (CIS) place a significant cost on families and society. According to recent research on the condition, immune-related damage is a major contributor to the development and occurrence of CIS. Innate immunity and adaptive immunity are the two primary categories of the immune system in the body. The body's first line of defense is innate immunity, and immune cells play a role in every stage of the immune system. At the same time, protein molecules play a vital function in regulating and differentiating immune cells. It can be said that protein molecules are the foundation of immune regulation. Model mice are necessary for us to examine fixed compounds in our studies. Conditional deletion and overexpression mouse models are the two primary categories of model mice. Numerous model mice have been documented in CIS research. The study of innate immune responses following ischemic stroke will benefit more from the use of these transgenic mice that target innate immunity. This paper analyzes the literature on transgenic mice related to innate immune responses following ischemic stroke because of the significance of these responses. It is anticipated to produce novel medications, improve clinical treatment guidance, and undergo a metamorphosis and application in the clinic in the future.
缺血性脑卒中（CIS）的高发病率、高死亡率、高致残率及高复发率给家庭和社会带来了巨大的负担。根据近期对该病症的研究，免疫相关损伤是CIS发生发展的主要因素。固有免疫和适应性免疫是机体免疫系统的两大主要类型。固有免疫是机体的第一道防线，免疫细胞在免疫系统的各个阶段都发挥着作用。同时，蛋白质分子在免疫细胞的调节和分化中起着至关重要的作用。可以说，蛋白质分子是免疫调节的基础。在我们的研究中，模型小鼠对于检测特定化合物是必不可少的。条件性敲除和过表达小鼠模型是模型小鼠的两大主要类型。在CIS研究中已经记录了许多模型小鼠。由于这些反应的重要性，对缺血性脑卒中后固有免疫反应的研究将更多地受益于使用这些针对固有免疫的转基因小鼠。由于这些反应的重要性，本文分析了与缺血性脑卒中后固有免疫反应相关的转基因小鼠的文献。预计未来将研发出新型药物，改善临床治疗指导，并在临床上实现变革与应用。
