Yang Fan, Hu Mengyuan, Zhang Haoyang, Zheng Xiaowei, Chen Limei, Zhu Lihong, Zhang Le
Department of Pediatric Laboratory, Affiliated Children's Hospital of Jiangnan University (Wuxi Children's Hospital), Wuxi, People's Republic of China.
Wuxi School of Medicine, Jiangnan University, Wuxi, People's Republic of China.
Diabetes Metab Syndr Obes. 2024 Dec 4;17:4627-4639. doi: 10.2147/DMSO.S492809. eCollection 2024.
Metabolic-associated steatotic liver disease (MASLD) is a novel term proposed in 2023 to replace non-alcoholic fatty liver disease (NAFLD) with the aim of better reflecting its pathogenesis and clinical manifestations. Vibration-controlled transient elastography (VCTE) is an evidence-based, non-invasive imaging device used to evaluate liver fat deposition and fibrosis. It can effectively detect liver fat infiltration greater than 5%, which is much higher than the previous ultrasound detection rate (it is difficult to detect liver fat deposition below 30%). Nevertheless, the prevalence and characteristics of MASLD children diagnosed based on these updated criteria are currently not well established.
Currently, a prospective multi-center population-based cohort study is being conducted in Wuxi, China, spanning from 2023 to 2035, involving 5600 children from four primary schools. Throughout the study's baseline and follow-up periods, yearly physical examinations, laboratory tests, VCTE assessments, and bioelectrical impedance analysis are being conducted to measure MASLD-related biomarkers. Additionally, a questionnaire is being administered to inquire about dietary habits. MASLD is being diagnosed based on clinical and laboratory criteria, and the corresponding prevalence is being assessed.
Recruitment began in March 13, 2023. To date, 1475 participants have completed the physical examination and questionnaire survey.
Our study investigated the prevalence of MASLD and its influencing factors in Chinese school-age children and adolescents. By collecting and analyzing data from physical examinations and survey questionnaires, it may propose new avenues for guiding the treatment and early-stage prevention of MASLD in children.
Chinese Clinical Trials Registry (NO. ChiCTR2400080508).
代谢相关脂肪性肝病（MASLD）是2023年提出的一个新术语，用于取代非酒精性脂肪性肝病（NAFLD），目的是更好地反映其发病机制和临床表现。振动控制瞬时弹性成像（VCTE）是一种基于证据的非侵入性成像设备，用于评估肝脏脂肪沉积和纤维化。它能有效检测出大于5%的肝脏脂肪浸润，远高于以往超声检测率（难以检测出低于30%的肝脏脂肪沉积）。然而，目前基于这些更新标准诊断的MASLD儿童的患病率和特征尚未明确。
目前，在中国无锡正在进行一项前瞻性多中心基于人群的队列研究，时间跨度为2023年至2035年，涉及来自四所小学的5600名儿童。在研究的基线期和随访期，每年进行体格检查、实验室检查、VCTE评估和生物电阻抗分析，以测量与MASLD相关的生物标志物。此外，还发放问卷询问饮食习惯。根据临床和实验室标准诊断MASLD，并评估相应的患病率。
招募工作于2023年3月13日开始。迄今为止，已有1475名参与者完成了体格检查和问卷调查。
我们的研究调查了中国学龄儿童和青少年中MASLD的患病率及其影响因素。通过收集和分析体格检查和调查问卷的数据，可能为指导儿童MASLD的治疗和早期预防提供新途径。
中国临床试验注册中心（编号：ChiCTR2400080508）。
