Vav家族交换因子：动脉粥样硬化中的潜在调节因子。
Vav family exchange factors: Potential regulator in atherosclerosis.
作者信息
Zhang Yu, Ren Yongwei, Zhou Tao, Qian Zhengtao, Bao Zhengyang
机构信息
Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, 214002, China.
Research Institute for Reproductive Health and Genetic Diseases, Wuxi Maternity and Child Health Care Hospital, Affiliated Women's Hospital of Jiangnan University, Wuxi, 214002, China.
出版信息
Biochem Biophys Rep. 2024 Nov 23;40:101878. doi: 10.1016/j.bbrep.2024.101878. eCollection 2024 Dec.
The Vav family of guanosine nucleotide exchange factors (GEFs) regulates the phosphorylation of tyrosinase, influencing various physiological and pathological processes by modulating the binding of Rho GTPases to GDP/GTP. Recent research has highlighted the critical role of Vav family activation in tumorigenesis, neurological disorders, immune-related dysfunctions, and other diseases. This review offers a comprehensive overview of the structure and function of Vav proteins and their significant impact on the pathophysiology of atherosclerosis. In addition, we pay attention to the development of diagnostic and therapeutic targets centered around Vav proteins.
鸟苷酸交换因子（GEF）的Vav家族调节酪氨酸酶的磷酸化，通过调节Rho GTP酶与GDP/GTP的结合来影响各种生理和病理过程。最近的研究强调了Vav家族激活在肿瘤发生、神经疾病、免疫相关功能障碍和其他疾病中的关键作用。本综述全面概述了Vav蛋白的结构和功能及其对动脉粥样硬化病理生理学的重大影响。此外，我们关注围绕Vav蛋白的诊断和治疗靶点的发展。
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