Thekho Apaopa Jemima, Mendiratta Vibhu, Garg Taru, Kaur Ravinder, Yadav Vidya
From the Department of Dermatology and STD, Lady Hardinge Medical College and Sucheta Kriplani Hospital, New Delhi, India.
Department of Microbiology, Lady Hardinge Medical College and Sucheta Kriplani Hospital, New Delhi, India.
Indian J Dermatol. 2024 Sep-Oct;69(5):422. doi: 10.4103/ijd.ijd_193_24. Epub 2024 Oct 29.
Vulvovaginal candidiasis (VVC) is a prevalent form of vaginitis, and most patients show improvement when treated with antifungal medications. However, recurrence may affect a minority. It has been found through previous research that the concomitant utilisation of probiotics during acute VVC leads to early relief of symptoms and signs and offers a preventive measure against recurrences.
This study aimed to assess the efficacy of the combination of oral probiotics with conventional antifungal treatment as compared to conventional antifungal treatment alone.
Sixty patients who were newly diagnosed with VVC were enrolled in a randomised controlled trial. They were divided into two groups. Group A included 30 cases treated with conventional antifungal medication (oral fluconazole 150 mg single dose), while Group B included 30 cases treated with conventional antifungal medication (oral fluconazole 150 mg single dose) alongside oral probiotic capsules (, , , ) for 2 months. The clinical and mycological findings were recorded before and after treatment. The relapse rate and side effects were recorded during the period of our study.
No significant difference between the clinical cure rate, mycological cure, and relapse rate was seen between the two groups. ( < 0.05). However, a larger proportion of patients in Group B (97%) achieved complete remission compared to Group A (90%). No side effects were noted in either of the groups.
Based on the findings, it can be concluded that the addition of probiotics to conventional antifungal treatment led to better rates of clinical and mycological cure and a lower likelihood of relapse compared to conventional antifungal treatment alone.
外阴阴道念珠菌病（VVC）是阴道炎的一种常见形式，大多数患者在接受抗真菌药物治疗后症状会有所改善。然而，少数患者可能会复发。先前的研究发现，在急性VVC期间同时使用益生菌可使症状和体征得到早期缓解，并提供预防复发的措施。
本研究旨在评估口服益生菌与传统抗真菌治疗联合使用相较于单纯传统抗真菌治疗的疗效。
60例新诊断为VVC的患者被纳入一项随机对照试验。他们被分为两组。A组包括30例接受传统抗真菌药物治疗（口服氟康唑150mg单剂量）的患者，而B组包括30例接受传统抗真菌药物治疗（口服氟康唑150mg单剂量）并同时口服益生菌胶囊（此处原文括号内容缺失，无法准确翻译）2个月的患者。记录治疗前后的临床和真菌学检查结果。在研究期间记录复发率和副作用。
两组之间的临床治愈率、真菌学治愈率和复发率均无显著差异（此处原文 < 0.05 不完整，无法准确翻译其含义）。然而,与A组（90%）相比，B组中有更大比例的患者（97%）实现了完全缓解。两组均未观察到副作用。
基于研究结果，可以得出结论，与单纯传统抗真菌治疗相比，在传统抗真菌治疗中添加益生菌可提高临床和真菌学治愈率，并降低复发可能性。
