Wolfe Gil I, Hanson Jonathan E, Silvestri Nicholas J
From the Dept. of Neurology, Jacobs School of Medicine and Biomedical Sciences, Univ. at Buffalo, State University of New York, Buffalo, NY, USA.
eNeurologicalSci. 2024 Nov 19;37:100541. doi: 10.1016/j.ensci.2024.100541. eCollection 2024 Dec.
Pharmacological options in the management of generalized myasthenia gravis (gMG) have expanded rapidly in the last 7 years. There are now several complement inhibitors and neonatal Fc receptor antagonists on the market in many countries for patient management, following the successful completion of Phase 3 studies. In open-label extensions, these agents have proven to be effective over the longer term extending several years, with benefits such as reduction of corticosteroid requirements being observed. In the communication below, we will briefly summarize recent pharmacologic advancements in the management of gMG and outline how these agents are currently being used and may be used in the future.
在过去7年中,全身型重症肌无力(gMG)的药物治疗选择迅速增加。在3期研究成功完成后,目前许多国家市场上有几种补体抑制剂和新生儿Fc受体拮抗剂用于患者管理。在开放标签扩展研究中,这些药物已被证明在长达数年的长期治疗中有效,观察到诸如减少皮质类固醇需求等益处。在以下交流中,我们将简要总结gMG治疗方面的近期药物进展,并概述这些药物目前的使用方式以及未来可能的使用方式。