Hawley Miranda, Smith Joe, Lawson Kaitlyn, Jansen Jocelyn, Crawford Rex, Adeniji Afolakemi, Bauman Cathy
Ontario Veterinary College, University of Guelph, Guelph, ON, Canada N1G 2W1.
SMART Pharmacology, Iowa State University, Ames, IA 50011.
JDS Commun. 2024 Jun 28;5(6):735-739. doi: 10.3168/jdsc.2024-0559. eCollection 2024 Nov.
In Canada, currently no antibiotics are approved for use in lactating dairy goats. Trimethoprim sulfadoxine is indicated for the treatment of bacterial pneumonia, enteric and septicemic colibacillosis and salmonellosis, infectious pododermatitis, and septicemias. The aim of this study was to determine the trimethoprim sulfadoxine withdrawal time and evaluate the test accuracy of the Charm Rapid One Step Assay (ROSA) SULF test (Charm Sciences Inc.) at the individual goat level. The study was conducted on 20 visibly healthy Ontario dairy goats. They received trimethoprim sulfadoxine at a dose of 16 mg/kg i.m. once a day for 5 d as the commercially available preparation trimethoprim sulfadoxine (Borgal, Merck Animal Health). Residue levels were measured using liquid chromatography-tandem mass spectrometry and the Charm ROSA SULF. The withdrawal time was calculated using safe concentration linear regression. The determined milk withdrawal time was 60 h.
在加拿大，目前没有抗生素被批准用于泌乳期奶山羊。甲氧苄啶磺胺多辛适用于治疗细菌性肺炎、肠道和败血性大肠杆菌病以及沙门氏菌病、传染性蹄皮炎和败血症。本研究的目的是确定甲氧苄啶磺胺多辛的停药时间，并在个体山羊水平评估Charm快速一步检测法（ROSA）磺胺检测（Charm Sciences Inc.）的检测准确性。该研究在20只外观健康的安大略省奶山羊上进行。它们以16毫克/千克的剂量肌肉注射甲氧苄啶磺胺多辛，每天一次，持续5天，使用市售制剂甲氧苄啶磺胺多辛（Borgal，默克动物保健）。使用液相色谱 - 串联质谱法和Charm ROSA SULF测量残留水平。停药时间通过安全浓度线性回归计算得出。确定的牛奶停药时间为60小时。
