Howard-Williams J, Patel P, Jelfs R, Carter R D, Awdry P, Bron A, Mann J I, Hockaday T D
Br J Ophthalmol. 1985 Jan;69(1):15-8. doi: 10.1136/bjo.69.1.15.
One hundred and forty nine diabetic patients were ophthalmologically assessed seven years after randomisation to a low carbohydrate or modified fat diet (rich in linoleic acid). Glycaemic control, regardless of the type of diet, was a major determinant of the development of retinopathy. Poorly controlled patients (haemoglobin A1c greater than 8%) with low levels of linoleic acid in cholesterol ester had a significantly greater frequency of retinopathy than well controlled patients or patients with similarly unsatisfactory control but higher levels of linoleic acid. The findings support an earlier suggestion that linoleic acid might protect against diabetic retinopathy.
149名糖尿病患者在被随机分配至低碳水化合物饮食或改良脂肪饮食（富含亚油酸）七年后接受了眼科评估。无论饮食类型如何，血糖控制都是视网膜病变发生的主要决定因素。胆固醇酯中亚油酸水平较低的血糖控制不佳患者（糖化血红蛋白大于8%），其视网膜病变的发生率明显高于血糖控制良好的患者或血糖控制同样不理想但亚油酸水平较高的患者。这些发现支持了早期的一种观点，即亚油酸可能预防糖尿病视网膜病变。
