Villagra Moran Vanina Myuriel, Nila Irin Sultana, Madhuvilakku Rajesh, Sumsuzzman Dewan Md, Khan Zeeshan Ahmad, Hong Yonggeun
Department of Physical Therapy, Graduate School of Inje University, Gimhae, Gyeongsangnam-do, Republic of Korea.
Biohealth Products Research Center (BPRC), Inje University, Gimhae, Gyeongsangnam-do, Republic of Korea.
BMJ Open Sport Exerc Med. 2024 Dec 5;10(4):e001906. doi: 10.1136/bmjsem-2024-001906. eCollection 2024.
This study aimed to investigate the role of physical exercises as a non-pharmacological intervention for ameliorating post-stroke dysregulated homeostatic parameters.
Embase, PubMed, PEDro, ISI Web of Science and CENTRAL were searched until April 2024. Parallel randomised controlled trials (RCTs) analysing the effect of post-stroke physical exercises (PSPE) on homeostatic parameters such as blood glucose, oxygen consumption (VO), high-density lipoprotein (HDL), low-density lipoprotein (LDL), systolic (SBP) and diastolic blood pressure (DBP) in individuals with stroke were selected.
Sixteen RCTs (n=698) were included. PSPE reduced fasting glucose levels (MD=-0.22; 95% CI -0.22 to -0.02; p=0.00) and increased the VO (MD=2.51; 95% CI 1.65 to 3.37; p=0.00) and blood HDL levels (MD=0.07; 95% CI 0.00 to 0.13; p=0.00). However, we did not observe beneficial effects on LDL, SBP and DBP parameters. Further analyses demonstrated that both low and moderate exercises are more suitable for improving blood glucose and VO in this population.
PSPE have the potential to improve dysregulated post-stroke parameters by reducing blood glucose levels and increasing VO and HDL levels. However, the small size and limited number of included studies limited the precision of our results. Further research is needed to comprehensively analyse the effects of PSPE, particularly on LDL levels and blood pressure.
CRD42023395715.
本研究旨在探讨体育锻炼作为一种非药物干预措施对改善中风后体内稳态参数失调的作用。
检索截至2024年4月的Embase、PubMed、PEDro、ISI Web of Science和CENTRAL数据库。选择平行随机对照试验（RCT），分析中风后体育锻炼（PSPE）对中风患者血糖、耗氧量（VO）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、收缩压（SBP）和舒张压（DBP）等体内稳态参数的影响。
纳入16项RCT（n = 698）。PSPE降低了空腹血糖水平（MD = -0.22；95%CI -0.22至-0.02；p = 0.00），增加了VO（MD = 2.51；95%CI 1.65至3.37；p = 0.00）和血液HDL水平（MD = 0.07；95%CI 0.00至0.13；p = 0.00）。然而，我们未观察到对LDL、SBP和DBP参数有有益影响。进一步分析表明，低强度和中等强度运动更适合改善该人群的血糖和VO。
PSPE有可能通过降低血糖水平、增加VO和HDL水平来改善中风后失调的参数。然而，纳入研究的样本量小且数量有限，限制了我们结果的精确性。需要进一步研究以全面分析PSPE的影响，特别是对LDL水平和血压影响。
PROSPERO注册号：CRD42023395715。
