Mackett R L, Guay D R
Can Med Assoc J. 1985 Jan 1;132(1):39-40.
Although rare, neutropenia associated with long-term vancomycin therapy may occur. A 67-year-old woman with cellulitis and sepsis caused by Staphylococcus aureus was treated initially with cefazolin. Despite in-vitro susceptibility of the organism to this drug, the patient remained febrile, and therapy was changed to vancomycin. On day 17 of therapy with this medication neutropenia was noted; it progressed over the next 3 days, and therapy with the drug was stopped. A rise in the neutrophil count occurred within 5 days of discontinuation. Periodic monitoring of the leukocyte count during longterm vancomycin therapy is recommended.
虽然罕见，但长期使用万古霉素治疗可能会导致中性粒细胞减少。一名67岁患有金黄色葡萄球菌引起的蜂窝织炎和脓毒症的女性最初接受头孢唑林治疗。尽管该病菌在体外对这种药物敏感，但患者仍持续发热，于是治疗改为使用万古霉素。在使用该药物治疗的第17天发现了中性粒细胞减少；在接下来的3天里病情进展，于是停止了该药物治疗。停药后5天内中性粒细胞计数有所上升。建议在长期使用万古霉素治疗期间定期监测白细胞计数。
