Weitzman S A, Stossel T P
Lancet. 1978 May 20;1(8073):1068-72. doi: 10.1016/s0140-6736(78)90915-7.
Antineutrophil antibody capable of opsonising normal neutrophils was detected in the sera of 16 neutropenic patients receiving various drugs. A single drug was involved in 10 cases, multiple medication in 6. 4 patients received semisynthetic penicillins, 8 some form of antimicrobial, and 2 antithyroid agents. Neutrophil counts rose, and antineutrophil antibody activity declined or disappeared, after drug therapy was stopped. Opsonisation related to the semisynthetic penicillins was independent of complement but dependent on drug concentration. Complement-dependent opsonic activity was demonstrated in 2 patients (1 receiving methimazole and 1 receiving multiple medication) and in the patient receiving methimazole this activity was shown to reside in the IgM serum-fraction. In another patient receiving multiple drugs, a complement-independent IgG antibody was demonstrated.
在16名接受各种药物治疗的中性粒细胞减少患者的血清中检测到了能够调理正常中性粒细胞的抗中性粒细胞抗体。10例由单一药物引起，6例由多种药物引起。4例患者接受半合成青霉素治疗，8例接受某种形式的抗菌药物治疗，2例接受抗甲状腺药物治疗。停药后，中性粒细胞计数上升，抗中性粒细胞抗体活性下降或消失。与半合成青霉素相关的调理作用不依赖补体，但依赖药物浓度。在2例患者（1例接受甲巯咪唑治疗，1例接受多种药物治疗）中证实了补体依赖性调理活性，在接受甲巯咪唑治疗的患者中，这种活性存在于IgM血清组分中。在另一名接受多种药物治疗的患者中，证实了一种不依赖补体的IgG抗体。
