Gopal V, Bisno A L, Silverblatt F J
JAMA. 1976 Oct 4;236(14):1604-6.
In a case of staphylococcal endocarditis, we failed to eradicate Staphylococcus aureus from the blood stream with vancomycin hydrochloride therapy. The strain involved was sensitive to vancomycin by disk diffusion studies but showed a wide disparity between minimal inhibitory and minimal bactericidal concentrations. The lack of a bactericidal effect was probably responsible for the failure of treatment. A synergistic effect was demonstrated for the combination of gentamicin sulfate and methicillin sodium, and the patient was ultimately cured with this combination plus vancomycin. Bactericidal tests are important in choosing an antimicrobial agent for treatment of endocarditis.
在一例葡萄球菌性心内膜炎中，我们使用盐酸万古霉素治疗未能从血流中根除金黄色葡萄球菌。通过纸片扩散法研究，所涉及的菌株对万古霉素敏感，但在最低抑菌浓度和最低杀菌浓度之间显示出很大差异。缺乏杀菌作用可能是治疗失败的原因。硫酸庆大霉素和甲氧西林钠联合使用显示出协同作用，该患者最终用此联合用药加万古霉素治愈。杀菌试验对于选择治疗心内膜炎的抗菌药物很重要。
