Malakar Sayan, Kumar Sanjit, Rungta Sumit, Kothalkar Srikanth, Kumar Arvind, Kohli Krishna P, Jangra Rahul, Shukla Gaya P, Agarwal Mayank, Yadav Dheeraj, Parwar Anubhav, Mishra Saurabh, Bhardwaj Akriti
Gastroenterology, King George's Medical University, Lucknow, IND.
Cureus. 2024 Nov 7;16(11):e73260. doi: 10.7759/cureus.73260. eCollection 2024 Nov.
Hepatitis E is a hepatotropic virus and the most common cause of acute viral hepatitis among adults in India. It has four genotypes, and genotype 1 is mostly associated with sporadic cases. It typically causes self-limiting acute hepatitis following a prodromal course. However, a subset of patients presents with cholestatic features mimicking primary cholestatic liver diseases like primary biliary cholangitis or primary sclerosing cholangitis. Liver injury ranges from asymptomatic rise of liver enzymes to fulminant liver failure. The hepatitis E virus (HEV) has also been implicated in various extrahepatic manifestations such as acute pancreatitis, Guillain-Barré syndrome (GBS), radiculopathy, autoimmune hemolysis, and Bell's palsy. We present an interesting case of acute viral hepatitis E presenting with cholestatic jaundice and extrahepatic manifestations.
戊型肝炎是一种嗜肝病毒，是印度成年人急性病毒性肝炎最常见的病因。它有四种基因型，其中基因型1大多与散发病例相关。它通常在一段前驱期后引起自限性急性肝炎。然而，一部分患者会出现胆汁淤积性特征，类似于原发性胆汁性胆管炎或原发性硬化性胆管炎等原发性胆汁淤积性肝病。肝损伤范围从肝酶无症状升高到暴发性肝衰竭。戊型肝炎病毒（HEV）还与各种肝外表现有关，如急性胰腺炎、吉兰-巴雷综合征（GBS）、神经根病、自身免疫性溶血和贝尔麻痹。我们报告一例有趣的急性戊型病毒性肝炎病例，伴有胆汁淤积性黄疸和肝外表现。
