Lee Y M, Jackson S M
Cancer. 1985 Jan 15;55(2):450-2. doi: 10.1002/1097-0142(19850115)55:2<450::aid-cncr2820550227>3.0.co;2-1.
Six patients with primary seminoma of the mediastinum were treated at the Cancer Control Agency of British Columbia during the period from 1970 to 1982. Primary treatment used was external beam radiotherapy. Only one patient received both radiotherapy and chemotherapy. Tumor dose ranged from 3000 cGy in 16 daily fractions in 3 weeks to 3500 cGy in 20 daily fractions in 4 weeks using parallel opposed fields on megavoltage machines. Two patients received additional small-volume boost to the superior mediastinum, delivering 500 cGy and 1000 cGy, respectively. All patients had complete resolution of the mediastinal mass after treatment and are alive and free of disease. One patient developed a metastasis to the fifth lumbar vertebra 1 year after treatment. This metastatic lesion was treated with radiotherapy and the patient is alive and free of clinical disease. Mediastinal seminoma is radiosensitive and radiocurable.
1970年至1982年期间，不列颠哥伦比亚癌症控制局对6例原发性纵隔精原细胞瘤患者进行了治疗。采用的主要治疗方法是外照射放疗。只有1例患者同时接受了放疗和化疗。使用兆伏级机器的平行对置野，肿瘤剂量范围为3周内分16次每日照射3000厘戈瑞至4周内分20次每日照射3500厘戈瑞。2例患者对纵隔上部进行了额外的小体积加量照射，分别给予500厘戈瑞和1000厘戈瑞。所有患者治疗后纵隔肿块均完全消退，目前存活且无疾病。1例患者在治疗1年后发生第五腰椎转移。该转移病灶接受了放疗，患者目前存活且无临床疾病。纵隔精原细胞瘤对放疗敏感且可通过放疗治愈。
