Mullins Jordyn, Sheppard Cody, Beyer Brian R, Blacksten Cheri
Family Medicine, Burrell College of Osteopathic Medicine, Las Cruces, USA.
Cureus. 2024 Nov 7;16(11):e73219. doi: 10.7759/cureus.73219. eCollection 2024 Nov.
Stiff person spectrum disorder is a disease that involves a host of conditions that are associated with glutamic acid decarboxylase 65-kilodalton isoform autoantibodies. These conditions may include diabetes mellitus type 1, pernicious anemia, autoimmune leukoencephalopathy, cerebellar ataxia, and stiff-person syndrome. Clinical recognition and diagnosis of stiff person spectrum disorder are important early, as immunologic treatment options showing reliable efficacy in slowing disease progression are available. This case presents a wide constellation of symptoms in which we describe the pathophysiology, clinical diagnosis, and current as well as future treatment options that may be available. .
僵人谱系障碍是一种涉及一系列与谷氨酸脱羧酶65千道尔顿同工型自身抗体相关病症的疾病。这些病症可能包括1型糖尿病、恶性贫血、自身免疫性白质脑病、小脑共济失调和僵人综合征。早期对僵人谱系障碍进行临床识别和诊断很重要，因为有显示出在减缓疾病进展方面具有可靠疗效的免疫治疗选择。本病例呈现出一系列广泛的症状，我们将描述其病理生理学、临床诊断以及当前和未来可能可用的治疗选择。
