卵巢颗粒细胞瘤中的染色体变化：与癌的相似性。

Chromosomal changes in an ovarian granulosa cell tumor: similarity with carcinoma.

作者信息

Teyssier J R, Adnet J J, Pigeon F, Bajolle F

出版信息

Cancer Genet Cytogenet. 1985 Jan 1;14(1-2):147-52. doi: 10.1016/0165-4608(85)90225-0.

Abstract

The chromosomal changes in an ovarian granulosa cell tumor were studied after short-term culture in defined medium. The abnormalities found included X monosomy, structural rearrangements of chromosome #1, and an interstitial deletion of the long arm of chromosome #6. This pattern is closely related to that found in ovarian carcinoma and argues for the malignant nature of such tumors at the cellular level.

摘要

在限定培养基中短期培养后，对卵巢颗粒细胞瘤中的染色体变化进行了研究。发现的异常包括X单体性、1号染色体的结构重排以及6号染色体长臂的中间缺失。这种模式与在卵巢癌中发现的模式密切相关，表明此类肿瘤在细胞水平上具有恶性性质。