Verhest A, Nedoszytko B, Noel J C, Dangou J M, Simon P, Limon J
Department of Pathology and Gynecology, Erasme Hospital, Free University of Brussels, Belgium.
Cancer Genet Cytogenet. 1992 May;60(1):41-4. doi: 10.1016/0165-4608(92)90231-v.
We performed a cytogenetic study of an ovarian granulosa cell tumor (GCT). Tumor cells showed a translocation (6;16); the full karyotype was 45,XX-6,dic(6;16)(q11;q22)/44,XX,-6,-22,dic(6;16)(q11;q22),-22/46,XX,- 6,dic(6;16)(q11;q22), +dic(6;16)(q11;q22). This is the second case of GCT with structural changes of chromosome 6 leading to loss of 6q material.