Sufi S B, Donaldson A, Gandy S C, Jeffcoate S L, Chearskul S, Goh H, Hazra D, Romero C, Wang H Z
Clin Chem. 1985 Jan;31(1):101-3.
Blood samples can be difficult to obtain in studies involving serial sampling, especially in developing countries where there may also be logistic, ethical, and cultural constraints that make frequent blood collection impractical. Assays for steroids in saliva may avoid some of these difficulties. A multicenter study involving laboratories in five countries was carried out to compare the results of assays for salivary estradiol and progesterone performed with centrally provided reagents and assay protocols. Concentrations of salivary steroid as obtained by all but one center were comparable with those reported in the literature. We conclude that assays of hormones in saliva are useful adjuncts to those performed on other body fluids.
在涉及连续采样的研究中，获取血样可能很困难，尤其是在发展中国家，那里可能还存在后勤、伦理和文化方面的限制，使得频繁采集血液不切实际。唾液中类固醇的检测可能会避免其中一些困难。一项涉及五个国家实验室的多中心研究开展起来，以比较使用集中提供的试剂和检测方案进行的唾液雌二醇和孕酮检测结果。除一个中心外，所有中心获得的唾液类固醇浓度与文献报道的浓度相当。我们得出结论，唾液中激素的检测是对其他体液检测的有用辅助手段。
