Kasalović Mladen, Odalović Božidar, Mihajlović Lazar, Jakovljević Stefan, Elek Zlatan, Igrutinović Gojko, Anđelković Milena, Pajčin Mirjana
From the Surgical Clinic, Clinical Hospital Center Kosovska Mitrovica, Kosovska Mitrovica, Serbia.
From the Department of Surgery, Faculty of Medicine, University of Priština, Kosovska Mitrovica, Serbia.
Ann Saudi Med. 2024 Nov-Dec;44(6):422-434. doi: 10.5144/0256-4947.2024.422. Epub 2024 Dec 5.
Postoperative complications of colorectal cancer surgery contribute to increased morbidity and mortality in patients.
Investigate the role of biochemical markers in serum and peritoneal fluid in the development of postoperative complications in patients with enteral anastomosis.
Prospective.
University hospitals.
The studied population consisted of patients who underwent surgical treatment with created anastomosis or Hartmann's resection from April 2022 to April 2024, conducted at the Clinical-Hospital Center Kosovska Mitrovica and the University Clinical Center Kragujevac. Spearman's correlation coefficient (r) was used to test associations between categorical variables.
Lactate, albumin, lactate dehydrogenase, and IgA antibodies were monitored as predictors of anastomotic dehiscence and general postoperative complications.
The concentration of lactate in the drain fluid on the third postoperative day was statistically significantly higher in patients who did not develop anastomotic dehiscence (=.006). The concentration of IgA antibodies in the drain fluid on the third and fifth days post-surgery showed a moderate negative correlation with lactate concentration (r=-.670, =.012; r=-.577, =.039), repectively. There was a significantly higher concentration of albumin in the drain fluid on the third day post-surgery in patients who developed dehiscence (=.040), and on the seventh day post-surgery in those who did not develop dehiscence (=.001). The concentration of LDH on the third day in the drain fluid after surgery was statistically significantly higher in patients who did not develop dehiscence (=.020). There was a statistically significant difference in lactate concentration in the drain fluid on the third (<.001) and fifth days (=.041) post-surgery, as well as in albumin concentration on the third day post-surgery (=.024) with respect to the development of general postoperative complications.
This study revealed significant differences in the concentrations of lactate, albumin, and LDH in the drain fluid on the third and fifth days post-surgery with respect to the development of complications. These results suggest that monitoring these markers may help in the early identification of patients at risk of complications such as dehiscence.
Limited literature on specific aspects of this study, including the absence of a control group, small sample size, and two-center study.
结直肠癌手术的术后并发症会导致患者发病率和死亡率增加。
研究血清和腹腔积液中的生化标志物在肠吻合术后并发症发生中的作用。
前瞻性研究。
大学医院。
研究人群包括2022年4月至2024年4月在科索沃米特罗维察临床医院中心和克拉古耶瓦茨大学临床中心接受吻合术或哈特曼切除术的患者。采用斯皮尔曼相关系数（r）检验分类变量之间的关联。
监测乳酸、白蛋白、乳酸脱氢酶和IgA抗体，作为吻合口裂开和术后一般并发症的预测指标。
52例。
未发生吻合口裂开的患者术后第3天引流液中乳酸浓度在统计学上显著更高（P =.006）。术后第3天和第5天引流液中IgA抗体浓度与乳酸浓度分别呈中度负相关（r = -.670，P =.012；r = -.577，P =.039）。发生吻合口裂开的患者术后第3天引流液中白蛋白浓度显著更高（P =.040），未发生吻合口裂开的患者术后第7天引流液中白蛋白浓度显著更高（P =.001）。未发生吻合口裂开的患者术后第3天引流液中LDH浓度在统计学上显著更高（P =.020）。术后第3天（P <.001）和第5天（P =.041）引流液中乳酸浓度，以及术后第3天白蛋白浓度（P =.024）在术后一般并发症发生方面存在统计学显著差异。
本研究揭示了术后第3天和第5天引流液中乳酸、白蛋白和LDH浓度在并发症发生方面存在显著差异。这些结果表明，监测这些标志物可能有助于早期识别有吻合口裂开等并发症风险的患者。
关于本研究特定方面的文献有限，包括缺乏对照组、样本量小以及双中心研究。
