Li Yehua, Zhang Mengxian, Ma Xianrun, Chen Ye-Guang
Institute of Biomedical Innovation, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, 330031, China.
The State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
Cell Regen. 2024 Dec 9;13(1):28. doi: 10.1186/s13619-024-00214-w.
Intestinal epithelium regeneration is crucial for homeostatic maintenance of the intestinal functions. A recent study published in Nature uncovers tuft cells as an unexpected key player in the regenerative process. Human tuft cells, traditionally recognized for their involvement in immune defense and pathogen protection, were found to exhibit stem cell-like properties following radiation-induced injury. These cells not only resist damage but also have the ability to generate functional stem cells, promoting the repair of the intestinal epithelium. This finding suggests that tuft cells may function as a reserve pool of stem cells, essential for efficient intestinal regeneration after injury.
肠道上皮再生对于肠道功能的稳态维持至关重要。最近发表在《自然》杂志上的一项研究发现，簇细胞是再生过程中一个意想不到的关键参与者。传统上认为人类簇细胞参与免疫防御和病原体保护，研究发现它们在辐射诱导损伤后表现出干细胞样特性。这些细胞不仅能抵抗损伤，还具有产生功能性干细胞的能力，促进肠道上皮的修复。这一发现表明，簇细胞可能作为干细胞的储备库，对于损伤后高效的肠道再生至关重要。
