Jiang Mingqing, Xu Feng, Lei Ziye, Chen Xiu, Luo Hua, Zheng Zhong, Zhang Dechou, Lan Yongshu, Ruan Jianghai
Department of Neurology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China.
Laboratory of Neurological Diseases and Brain Function, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China.
Cerebellum. 2024 Dec 9;24(1):6. doi: 10.1007/s12311-024-01770-2.
To evaluate the alterations in brain dynamics in patients suffering from brainstem or cerebellar infarctions and their potential associations with cognitive function. In this study, 37 patients were recruited who had acute cerebellar infarction (CI), 32 patients who had acute brainstem infarction (BsI), and 40 healthy controls (HC). Every participant had their resting-state electroencephalogram (EEG) data captured, and the EEG microstates were analyzed. The cognitive function was measured by the Neuropsychological Cognitive Scale including the Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA), the Boston Naming Test (BNT), the Digit Span Test (Digitspan), and the Symbol Digit Modalities Test (SDMT). Compared with the HC group, the transition probabilities from Microstate A(MsA) and MsD to MsC significantly decreased while the transition probabilities from MsA to MsD and from MsD to MsB significantly increased in the BsI group. By contrast, the CI group showed a significant increase in transition probabilities from MsA and MsD to MsC, whereas the transitions from MsD to MsB significantly decreased. Subgroup analysis within the CI group demonstrated that the CI patients with dizziness showed increased coverage and duration in MsB but decreased MsD occurrence than those of CI patients with vertigo. In addition, the BsI patients with pons infarction performed a decreased transition probability between MsA and MsD than those of BsI patients with medulla oblongata infarctions. Moreover, the changes in Microstate (Ms) were significantly correlated with cognitive scales in patients with CI or BsI. Altered brain dynamics in patients with CI or BsI suggested that disturbances in resting brain networks might play a functional role in the cognitive impairment of the CI or BsI patients. Through the use of microstate analysis, the dizziness or vertigo following CI could be differentiated. These findings may serve as a powerful tool in our future clinical practices.
评估脑干或小脑梗死患者脑动力学的改变及其与认知功能的潜在关联。在本研究中，招募了37例急性小脑梗死（CI）患者、32例急性脑干梗死（BsI）患者和40名健康对照者（HC）。采集了每位参与者的静息态脑电图（EEG）数据，并对EEG微状态进行分析。认知功能通过神经心理学认知量表进行测量，包括简易精神状态检查表（MMSE）、蒙特利尔认知评估量表（MoCA）、波士顿命名测试（BNT）、数字广度测试（Digitspan）和符号数字模式测试（SDMT）。与HC组相比，BsI组中从微状态A（MsA）和MsD到MsC的转换概率显著降低，而从MsA到MsD以及从MsD到MsB的转换概率显著增加。相比之下，CI组中从MsA和MsD到MsC的转换概率显著增加，而从MsD到MsB的转换显著减少。CI组内的亚组分析表明，与有眩晕的CI患者相比，有头晕的CI患者MsB的覆盖范围和持续时间增加，但MsD的出现频率降低。此外，与延髓梗死的BsI患者相比，脑桥梗死的BsI患者在MsA和MsD之间的转换概率降低。此外，CI或BsI患者的微状态（Ms）变化与认知量表显著相关。CI或BsI患者脑动力学的改变表明，静息脑网络的紊乱可能在CI或BsI患者的认知障碍中起作用。通过使用微状态分析，可以区分CI后的头晕或眩晕。这些发现可能成为我们未来临床实践中的有力工具。
