University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland; Vilnius University, Life Sciences Center, Vilnius, Lithuania; Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.
University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Neuroscience. 2021 Dec 15;479:140-156. doi: 10.1016/j.neuroscience.2021.10.014. Epub 2021 Oct 21.
Patients with schizophrenia present with various symptoms related to different domains. Abnormalities of auditory and visual perception are parts of a more general problem. Nevertheless, the relationship between the lifetime history of auditory verbal hallucination (AVH), one of the most prevalent symptoms in schizophrenia, and visuospatial deficits remains unclear. This study aimed to investigate differences in hemispheric involvement and visuospatial processing between healthy controls (HCs) and schizophrenia patients with and without AVHs. HCs (N = 20), schizophrenia patients with AVH (AVH group, N = 16), and schizophrenia patients without hallucinations (NH group, N = 10) participated in a 4-choice reaction task with lateralized stimuli. An event-related potential (ERP)-microstate approach was used to analyze ERP differences between the conditions and groups. The schizophrenia patients without hallucinations had slower responses than the HCs. An early visual N1 contralateral to stimulation side was prominent in all groups of participants but with decreased amplitude in the patients with schizophrenia, especially in the AVH group over the right hemisphere. The amplitude of P3b, a cognitive evaluation component, was also decreased in schizophrenia. Compared to AVH and HC groups, the patients in the NH group had altered microstate patterns: P3b was replaced by a novelty component, P3a. Although the difference between both patient groups was only based on the presence of AVHs, our findings indicated that patients had specific visuospatial deficits associated with a lifetime history of hallucinations: patients with AVHs showed early visual component alterations in the right hemisphere, and those without AVHs had more prominent visuospatial impairment.
精神分裂症患者表现出与不同领域相关的各种症状。听觉和视觉感知异常是更普遍问题的一部分。然而，精神分裂症最常见症状之一的幻听（AVH）的终身病史与视空间缺陷之间的关系仍不清楚。本研究旨在调查健康对照组（HCs）和有和无 AVH 的精神分裂症患者之间半球参与和视空间处理的差异。HCs（N=20）、有 AVH 的精神分裂症患者（AVH 组，N=16）和无幻觉的精神分裂症患者（NH 组，N=10）参与了带有侧化刺激的 4 选择反应任务。采用事件相关电位（ERP）-微观状态方法分析条件和组之间的 ERP 差异。无幻觉的精神分裂症患者的反应比 HCs 慢。所有参与者组都表现出明显的对侧刺激的早期视觉 N1，但精神分裂症患者的振幅降低，尤其是右半球的 AVH 组。认知评估成分 P3b 的振幅也降低了。与 AVH 和 HC 组相比，NH 组的患者的微观状态模式发生了改变：P3b 被新颖性成分 P3a 取代。尽管这两个患者组之间的差异仅基于 AVHs 的存在，但我们的研究结果表明，患者存在与幻听的终身病史相关的特定视空间缺陷：有 AVHs 的患者在右半球显示出早期视觉成分改变，而没有 AVHs 的患者则表现出更明显的视空间障碍。
